Biomaterial Database

Persistent infection of mice with Pichinde virus associated with failure to thrive. 1995

K E Wright, and R Ahmed, and M J Buchmeier

Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA.

Intracranial inoculation of neonatal mice of certain inbred strains with Pichinde virus has been found to be fatal, but Balb/c neonates survive such infection. Survival of Balb/c mice after neonatal inoculation was not linked to the major histocompatability complex. Virus was gradually cleared in surviving Balb/c mice but could be detected in the brain and kidneys for up to 9 months after infection. These animals were not immunologically tolerant but exhibited high antibody titers to viral antigens. MHC restricted cytotoxic T cell activity was also demonstrable in persistently infected mice following challenge with high titered virus. Pathological changes consistent with glomerulonephritis were observed in the kidneys and surviving mice were runted compared to normals. This model differs from the widely studied persistent infection of mice with lymphocytic choriomeningitis virus (LCMV) and provides a unique model for the study of the genetics of resistance to viral infection, mechanisms of persistence and pathological processes in chronic viral infections.

UI	MeSH Term	Description	Entries
D008815	Mice, Inbred Strains	Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.	Inbred Mouse Strains,Inbred Strain of Mice,Inbred Strain of Mouse,Inbred Strains of Mice,Mouse, Inbred Strain,Inbred Mouse Strain,Mouse Inbred Strain,Mouse Inbred Strains,Mouse Strain, Inbred,Mouse Strains, Inbred,Strain, Inbred Mouse,Strains, Inbred Mouse
D002460	Cell Line	Established cell cultures that have the potential to propagate indefinitely.	Cell Lines,Line, Cell,Lines, Cell
D002522	Chlorocebus aethiops	A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.	African Green Monkey,Cercopithecus aethiops,Cercopithecus griseoviridis,Cercopithecus griseus,Cercopithecus pygerythrus,Cercopithecus sabeus,Cercopithecus tantalus,Chlorocebus cynosuros,Chlorocebus cynosurus,Chlorocebus pygerythrus,Green Monkey,Grivet Monkey,Lasiopyga weidholzi,Malbrouck,Malbrouck Monkey,Monkey, African Green,Monkey, Green,Monkey, Grivet,Monkey, Vervet,Savanah Monkey,Vervet Monkey,Savannah Monkey,African Green Monkey,Chlorocebus cynosuro,Green Monkey, African,Green Monkeys,Grivet Monkeys,Malbrouck Monkeys,Malbroucks,Monkey, Malbrouck,Monkey, Savanah,Monkey, Savannah,Savannah Monkeys,Vervet Monkeys
D002908	Chronic Disease	Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).	Chronic Condition,Chronic Illness,Chronically Ill,Chronic Conditions,Chronic Diseases,Chronic Illnesses,Condition, Chronic,Disease, Chronic,Illness, Chronic
D004195	Disease Models, Animal	Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	Animal Disease Model,Animal Disease Models,Disease Model, Animal
D005183	Failure to Thrive	A condition of substandard growth or diminished capacity to maintain normal function.	Thrive, Failure to
D006478	Hemorrhagic Fever, American	Diseases caused by American hemorrhagic fever viruses (ARENAVIRUSES, NEW WORLD).	American Hemorrhagic Fever,Argentine Hemorrhagic Fever,Bolivian Hemorrhagic Fever,Brazilian Hemorrhagic Fever,Hemorrhagic Fever, Argentinian,Hemorrhagic Fever, Bolivian,Hemorrhagic Fever, Brazilian,Junin virus Infection,Machupo virus Infection,Sabia virus Infection,American Hemorrhagic Fevers,Argentinian Hemorrhagic Fever,Bolivian Hemorrhagic Fevers,Brazilian Hemorrhagic Fevers,Fever, American Hemorrhagic,Fever, Argentine Hemorrhagic,Fever, Argentinian Hemorrhagic,Fever, Bolivian Hemorrhagic,Fever, Brazilian Hemorrhagic,Hemorrhagic Fever, Argentine,Infection, Junin virus,Infection, Machupo virus,Infection, Sabia virus,Junin virus Infections,Machupo virus Infections,Sabia virus Infections
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000831	Animals, Newborn	Refers to animals in the period of time just after birth.	Animals, Neonatal,Animal, Neonatal,Animal, Newborn,Neonatal Animal,Neonatal Animals,Newborn Animal,Newborn Animals
D014709	Vero Cells	A CELL LINE derived from the kidney of the African green (vervet) monkey, (CHLOROCEBUS AETHIOPS) used primarily in virus replication studies and plaque assays.	Cell, Vero,Cells, Vero,Vero Cell