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The effect of isradipine, a dihydropyridine calcium antagonist, on intravenous self-administration of nicotine in naive mice has been investigated. When nicotine injections were made contingent upon nose-poke response by naive mice, they increased their rate of nose poking with respect to animals receiving contingent saline injections or yoked control animals receiving noncontingent nicotine injections. Pretreatment of mice with mecamylamine (2.4 mg/kg) inhibited self-administration of nicotine contingent upon a nose-poke response. The same effect was observed with isradipine (0.5-1.0 mg/kg) in a dose-related manner and stereospecifically. These data suggest that isradipine suppresses the reinforcing properties of nicotine and might be useful for treatment of nicotine abuse.
M C Martellotta, and
A Kuzmin, and
E Zvartau, and
G Cossu, and
G L Gessa, and
W Fratta
December 1998,
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology,
M C Martellotta, and
A Kuzmin, and
E Zvartau, and
G Cossu, and
G L Gessa, and
W Fratta
June 1998,
Pharmacology, biochemistry, and behavior,
M C Martellotta, and
A Kuzmin, and
E Zvartau, and
G Cossu, and
G L Gessa, and
W Fratta
March 1983,
Pharmacology, biochemistry, and behavior,
M C Martellotta, and
A Kuzmin, and
E Zvartau, and
G Cossu, and
G L Gessa, and
W Fratta
January 2000,
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
M C Martellotta, and
A Kuzmin, and
E Zvartau, and
G Cossu, and
G L Gessa, and
W Fratta
January 2007,
Behavior genetics,
M C Martellotta, and
A Kuzmin, and
E Zvartau, and
G Cossu, and
G L Gessa, and
W Fratta
January 2002,
Alcohol and alcoholism (Oxford, Oxfordshire),
M C Martellotta, and
A Kuzmin, and
E Zvartau, and
G Cossu, and
G L Gessa, and
W Fratta
August 2005,
Current protocols in neuroscience,
M C Martellotta, and
A Kuzmin, and
E Zvartau, and
G Cossu, and
G L Gessa, and
W Fratta
December 2000,
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology,
M C Martellotta, and
A Kuzmin, and
E Zvartau, and
G Cossu, and
G L Gessa, and
W Fratta
August 2000,
European journal of pharmacology,
M C Martellotta, and
A Kuzmin, and
E Zvartau, and
G Cossu, and
G L Gessa, and
W Fratta
April 1993,
Brain research,
