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57 patients with newly diagnosed intermediate or high grade non-Hodgkin's lymphoma with stage II to IV disease were treated with P-COMM-B (prednisolone, cyclophosphamide, vincristine, mitozantrone, methotrexate and bleomycin). 46% patients achieved a complete remission and 26% achieved a partial remission. Projected disease-free survival in complete remission at 5 years is 56% and projected overall survival at 5 years is 37%. Neutropenia and proximal myopathy were the commonest severe toxicities encountered and two deaths were clearly related to treatment (3.5%). P-COMM-B is effective first-line chemotherapy in intermediate and high grade non-Hodgkin's lymphoma. The efficacy and toxicity of P-COMM-B appear to be comparable to those of the best contemporary regimen, CHOP.
J K Phillips, and
C Sherlaw-Johnson, and
J M Davies, and
J V Clough, and
H Parry, and
J R Nash, and
J C Cawley
January 1990,
Blut,
J K Phillips, and
C Sherlaw-Johnson, and
J M Davies, and
J V Clough, and
H Parry, and
J R Nash, and
J C Cawley
January 1994,
Acta oncologica (Stockholm, Sweden),
J K Phillips, and
C Sherlaw-Johnson, and
J M Davies, and
J V Clough, and
H Parry, and
J R Nash, and
J C Cawley
October 1993,
British journal of cancer,
J K Phillips, and
C Sherlaw-Johnson, and
J M Davies, and
J V Clough, and
H Parry, and
J R Nash, and
J C Cawley
January 1989,
Cancer chemotherapy and pharmacology,
J K Phillips, and
C Sherlaw-Johnson, and
J M Davies, and
J V Clough, and
H Parry, and
J R Nash, and
J C Cawley
January 1991,
Cancer chemotherapy and pharmacology,
J K Phillips, and
C Sherlaw-Johnson, and
J M Davies, and
J V Clough, and
H Parry, and
J R Nash, and
J C Cawley
May 1997,
Zhonghua zhong liu za zhi [Chinese journal of oncology],
J K Phillips, and
C Sherlaw-Johnson, and
J M Davies, and
J V Clough, and
H Parry, and
J R Nash, and
J C Cawley
November 1998,
The New England journal of medicine,
J K Phillips, and
C Sherlaw-Johnson, and
J M Davies, and
J V Clough, and
H Parry, and
J R Nash, and
J C Cawley
November 1998,
The New England journal of medicine,
J K Phillips, and
C Sherlaw-Johnson, and
J M Davies, and
J V Clough, and
H Parry, and
J R Nash, and
J C Cawley
November 1998,
The New England journal of medicine,
J K Phillips, and
C Sherlaw-Johnson, and
J M Davies, and
J V Clough, and
H Parry, and
J R Nash, and
J C Cawley
November 1998,
The New England journal of medicine,
