-transparent.png){kind=logo}
To assess the effects of lactate on glucose metabolism, sodium lactate (20 mumol.kg-1.min-1) was infused into healthy subjects in basal conditions and during application of a hyperinsulinaemic (6 pmol.kg-1.min-1) euglycaemic clamp. Glucose rate of appearance (GRa) and disappearance (GRd) were measured from plasma dilution of infused U- 13C glucose, and glucose oxidation (G(ox)) from breath 13CO2 and plasma 13C glucose. In basal conditions, lactate infusion did not alter G(ox) (8.8 +/- 0.9 vs 9.2 +/- 1.1 mumol.kg-1.min-1), while GRa slightly decreased from 15.2 +/- 0.8 basal to 13.9 +/- 0.9 mumol.kg-1.min-1 after lactate (p < 0.05). During a hyperinsulinaemic clamp, hepatic glucose production was completely suppressed with or without lactate. Lactate decreased G(ox) from 17.1 +/- 0.4 to 13.4 +/- 1.2 mumol.kg-1.min-1 (p < 0.05), whereas GRd was unchanged (39.7 +/- 3.6 vs 45.6 +/- 2.6 mumol.kg-1.min-1. It is concluded that infusion of lactate in basal conditions does not increase GRa or interfere with peripheral glucose oxidation, and that during hyperinsulinaemia lactate decreases glucose oxidation but does not alter hepatic or peripheral insulin sensitivity.
N Paquot, and
P Schneiter, and
M C Cayeux, and
R Chiolero, and
E Temler, and
E Jequier, and
L Tappy
July 1996,
Clinical physiology (Oxford, England),
N Paquot, and
P Schneiter, and
M C Cayeux, and
R Chiolero, and
E Temler, and
E Jequier, and
L Tappy
May 1994,
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity,
N Paquot, and
P Schneiter, and
M C Cayeux, and
R Chiolero, and
E Temler, and
E Jequier, and
L Tappy
November 1993,
The American journal of clinical nutrition,
N Paquot, and
P Schneiter, and
M C Cayeux, and
R Chiolero, and
E Temler, and
E Jequier, and
L Tappy
July 1996,
Clinical physiology (Oxford, England),
N Paquot, and
P Schneiter, and
M C Cayeux, and
R Chiolero, and
E Temler, and
E Jequier, and
L Tappy
June 1954,
The American journal of physiology,
N Paquot, and
P Schneiter, and
M C Cayeux, and
R Chiolero, and
E Temler, and
E Jequier, and
L Tappy
July 2012,
Critical care (London, England),
N Paquot, and
P Schneiter, and
M C Cayeux, and
R Chiolero, and
E Temler, and
E Jequier, and
L Tappy
August 1997,
The American journal of physiology,
N Paquot, and
P Schneiter, and
M C Cayeux, and
R Chiolero, and
E Temler, and
E Jequier, and
L Tappy
April 1995,
The American journal of physiology,
N Paquot, and
P Schneiter, and
M C Cayeux, and
R Chiolero, and
E Temler, and
E Jequier, and
L Tappy
February 2023,
bioRxiv : the preprint server for biology,
N Paquot, and
P Schneiter, and
M C Cayeux, and
R Chiolero, and
E Temler, and
E Jequier, and
L Tappy
November 1994,
The American journal of physiology,
