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In 12 anesthetized, open-chest mongrel dogs, endothelin-1 (ET-1) was infused into the left anterior descending coronary artery through an indwelling catheter at a dose of 30 pmol.min-1 for 30 min (n = 8). In four dogs the ET-1 dose was increased to 60 pmol/min for 10 min. Programmed electrical stimulation was used for electrophysiologic studies. Coronary blood flow was reduced by 32% on average without any ischemic ECG signs. QT time (186 +/- 3 ms vs. 218 +/- 6, p < 0.05, and 225 +/- 9, p < 0.05, p < 0.05). Ventricular irritability increased in all cases; ventricular extrasystoles, and nonsustained and sustained tachycardias occurred and, in 11 cases, ventricular fibrillation terminated the experiments. In two dogs, early afterdepolarization was recorded. Therefore, ET-1 is capable of inducing fatal ventricular arrythmias at least partly independent of its vasoconstrictor effect. QT prolongation appears to have a pathophysiologic role in this arrythmogenic effect.
M Tóth, and
F Solti, and
B Merkely, and
V Kékesi, and
F Horkay, and
I Szokodi, and
A Juhász-Nagy
August 2002,
Clinical science (London, England : 1979),
M Tóth, and
F Solti, and
B Merkely, and
V Kékesi, and
F Horkay, and
I Szokodi, and
A Juhász-Nagy
February 1978,
Clinical science and molecular medicine,
M Tóth, and
F Solti, and
B Merkely, and
V Kékesi, and
F Horkay, and
I Szokodi, and
A Juhász-Nagy
January 2003,
Pharmacology & toxicology,
M Tóth, and
F Solti, and
B Merkely, and
V Kékesi, and
F Horkay, and
I Szokodi, and
A Juhász-Nagy
February 1992,
Journal of cardiovascular pharmacology,
M Tóth, and
F Solti, and
B Merkely, and
V Kékesi, and
F Horkay, and
I Szokodi, and
A Juhász-Nagy
December 1996,
Journal of cardiothoracic and vascular anesthesia,
M Tóth, and
F Solti, and
B Merkely, and
V Kékesi, and
F Horkay, and
I Szokodi, and
A Juhász-Nagy
November 2004,
Journal of cardiovascular pharmacology,
M Tóth, and
F Solti, and
B Merkely, and
V Kékesi, and
F Horkay, and
I Szokodi, and
A Juhász-Nagy
May 1988,
Presse medicale (Paris, France : 1983),
M Tóth, and
F Solti, and
B Merkely, and
V Kékesi, and
F Horkay, and
I Szokodi, and
A Juhász-Nagy
November 2000,
Brain research,
M Tóth, and
F Solti, and
B Merkely, and
V Kékesi, and
F Horkay, and
I Szokodi, and
A Juhász-Nagy
January 1988,
Pharmacotherapy,
M Tóth, and
F Solti, and
B Merkely, and
V Kékesi, and
F Horkay, and
I Szokodi, and
A Juhász-Nagy
December 1990,
Cardiovascular research,
