Biomaterial Database

Coronary vascular effects of endothelin-1 during arterial hypotension. 1995

N Fernández, and A L García-Villalón, and L Monge, and B Gómez, and G Diéguez

Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma, Madrid, Spain.

Endothelin-1 (ET-1) effects on left circumflex coronary artery (LCCA) flow, systemic arterial pressure, heart rate, and left ventricle (LV) pressure and dP/dt were recorded in five anesthetized goats under control conditions and during arterial hypotension. Hypotension, induced by mechanical constriction of the inferior vena cava, reduced mean systemic arterial pressure from 92 +/- 4 to 59 +/- 4 mm Hg (p < 0.002), LCCA flow from 26 +/- 4 to 17 +/- 3 ml/min (p < 0.01), systolic LV pressure from 108 +/- 2.5 to 79 +/- 2 mm Hg (p < 0.002), and peak systolic LV dP/dt from 1,500 +/- 106 to 990 +2- 130 mm Hg/s (p < 0.02). Heart rate did not change (p > 0.05). ET-1 (0.01-0.1 nmol) injected into LCCA reduced LCCA flow in a dose-dependent manner without affecting the other variables recorded during control periods (C) and hypotension (H). The percentage reductions of LCCA flow by ET-1 were: for 0.01 nmol, 4.5 +/- 2 (C) vs. 11 +/- 2 (H) (p < 0.05); for 0.03 nmol, 15 +/- 2 (C) vs. 32 +/- 4 (H) (p < 0.05); and for 0.1 nmol, 44 +/- 5 (C) vs. 67 +/- 5 (H) (p < 0.05). This indicates that the coronary vasoconstrictor effects of ET-1 are increased during hypotension. Therefore, heart ischemia may be aggravated in situations of arterial hypotension with increased plasma concentrations of ET-1.

UI	MeSH Term	Description	Entries
D007022	Hypotension	Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.	Blood Pressure, Low,Hypotension, Vascular,Low Blood Pressure,Vascular Hypotension
D003331	Coronary Vessels	The veins and arteries of the HEART.	Coronary Arteries,Sinus Node Artery,Coronary Veins,Arteries, Coronary,Arteries, Sinus Node,Artery, Coronary,Artery, Sinus Node,Coronary Artery,Coronary Vein,Coronary Vessel,Sinus Node Arteries,Vein, Coronary,Veins, Coronary,Vessel, Coronary,Vessels, Coronary
D005260	Female		Females
D006041	Goats	Any of numerous agile, hollow-horned RUMINANTS of the genus Capra, in the family Bovidae, closely related to the SHEEP.	Capra,Capras,Goat
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D016232	Endothelins	21-Amino-acid peptides produced by vascular endothelial cells and functioning as potent vasoconstrictors. The endothelin family consists of three members, ENDOTHELIN-1; ENDOTHELIN-2; and ENDOTHELIN-3. All three peptides contain 21 amino acids, but vary in amino acid composition. The three peptides produce vasoconstrictor and pressor responses in various parts of the body. However, the quantitative profiles of the pharmacological activities are considerably different among the three isopeptides.	Endothelium-Derived Vasoconstrictor Factors,Endothelin,Vasoconstrictor Factors, Endothelium-Derived
D066298	In Vitro Techniques	Methods to study reactions or processes taking place in an artificial environment outside the living organism.	In Vitro Test,In Vitro Testing,In Vitro Tests,In Vitro as Topic,In Vitro,In Vitro Technique,In Vitro Testings,Technique, In Vitro,Techniques, In Vitro,Test, In Vitro,Testing, In Vitro,Testings, In Vitro,Tests, In Vitro,Vitro Testing, In