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Diabetes is associated with decreased protein synthesis; however, there have been very few studies on the effects of insulin or diabetes on mitochondrial protein synthesis. We have recently shown that insulin has a direct stimulatory effect on mitochondrial protein synthesis in isolated rat hepatocytes. In this study we demonstrate that mitochondrial protein synthesis is severely curtailed in hepatocytes isolated from diabetic rats and is unresponsive to in vitro insulin addition. Treatment of diabetic rats with insulin for three days partially restored tracer carbon incorporation in mitochondrial proteins. These results suggest that insulin stimulates hepatic mitochondrial protein synthesis which is significantly impaired in diabetes.
R A Memon, and
C Mohan, and
S P Bessman
January 2004,
Diabetes/metabolism research and reviews,
R A Memon, and
C Mohan, and
S P Bessman
August 2012,
Biochimica et biophysica acta,
R A Memon, and
C Mohan, and
S P Bessman
September 1996,
Japanese circulation journal,
R A Memon, and
C Mohan, and
S P Bessman
January 2011,
International journal of molecular sciences,
R A Memon, and
C Mohan, and
S P Bessman
December 1979,
FEBS letters,
R A Memon, and
C Mohan, and
S P Bessman
May 2008,
Hepatology (Baltimore, Md.),
R A Memon, and
C Mohan, and
S P Bessman
April 1992,
Endocrinologia japonica,
R A Memon, and
C Mohan, and
S P Bessman
September 2011,
Biochimica et biophysica acta,
R A Memon, and
C Mohan, and
S P Bessman
May 2020,
Mitochondrion,
R A Memon, and
C Mohan, and
S P Bessman
October 1980,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
