-transparent.png){kind=logo}
The correlation between the bromodeoxiuridine (BrdU)-labelling index (LI) of plasma cells and a new proliferation marker, the Argyrophilic Nucleolar Organizer Regions (AgNORs), was investigated in 44 myeloma patients at diagnosis. A preliminary analysis was made to verify the reproducibility of the assessment of plasma cell infiltration (PC%) in bone marrow aspirates, used to collect cells for LI determination, and in bone marrow biopsies, used for AgNORs evaluation. Although an overall good correlation was observed between PC% in biopsies and aspirates (r=0.58, p=0.001), the ratio between PC% in biopsies and in aspirates ranged form 0.35 to 7.5. Only 17 patients (38.6%) were within the 0.5-1.5 range. A positive correlation between LI and AgNORs was observed in these patients (r=0.68, p=0.003), whereas the correlation was lost in patients with higher ratio between PC% in biopsies and in aspirates (r=0.08, p=0.69). The prognostic significance of AgNORs was confirmed by survival analysis, showing a reduced survival for patients with high (>4.4) AgNOR counts (14 months vs 35 months, p=0.004). The AgNORs analysis therefore allows the simultaneous evaluation of myeloma cell infiltration, degree of differentiation and kinetics of growth in bone marrow biopsies. AgNOR counts deserve to be included in the procedures for diagnosis and prognostic evaluation of myeloma patients.
F Marmont, and
A Pich, and
L Chiusa, and
F Locatelli, and
M Falda, and
M Boccadoro, and
L Resegotti
September 1994,
Cancer,
F Marmont, and
A Pich, and
L Chiusa, and
F Locatelli, and
M Falda, and
M Boccadoro, and
L Resegotti
December 1992,
International journal of pancreatology : official journal of the International Association of Pancreatology,
F Marmont, and
A Pich, and
L Chiusa, and
F Locatelli, and
M Falda, and
M Boccadoro, and
L Resegotti
June 2010,
Cancer investigation,
F Marmont, and
A Pich, and
L Chiusa, and
F Locatelli, and
M Falda, and
M Boccadoro, and
L Resegotti
October 1989,
American journal of clinical pathology,
F Marmont, and
A Pich, and
L Chiusa, and
F Locatelli, and
M Falda, and
M Boccadoro, and
L Resegotti
January 1991,
Dermatologica,
F Marmont, and
A Pich, and
L Chiusa, and
F Locatelli, and
M Falda, and
M Boccadoro, and
L Resegotti
May 1991,
Pathology, research and practice,
F Marmont, and
A Pich, and
L Chiusa, and
F Locatelli, and
M Falda, and
M Boccadoro, and
L Resegotti
January 1994,
Virchows Archiv : an international journal of pathology,
F Marmont, and
A Pich, and
L Chiusa, and
F Locatelli, and
M Falda, and
M Boccadoro, and
L Resegotti
November 1995,
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology,
F Marmont, and
A Pich, and
L Chiusa, and
F Locatelli, and
M Falda, and
M Boccadoro, and
L Resegotti
January 1992,
Dermatology (Basel, Switzerland),
F Marmont, and
A Pich, and
L Chiusa, and
F Locatelli, and
M Falda, and
M Boccadoro, and
L Resegotti
March 1998,
Human pathology,
