-transparent.png){kind=logo}
OBJECTIVE To determine whether pupillary responses to dilute tropicamide could be used as a diagnostic test for Alzheimer disease (AD). The authors also investigated whether concurrent use of an oral acetylcholinesterase inhibitor (tacrine) alters the pupillary response to dilute tropicamide in patients with AD, and whether pupillary responses to dilute tropicamide differ in young versus older control subjects. METHODS Pupillary diameter and area of both eyes were measured in light and darkness, at 10-minute intervals for 40 minutes after random instillation of 0.01% tropicamide to one eye. Four groups of subjects were studied: 9 patients with AD, 10 who were treated with tacrine, 11 older control subjects, and 10 young control subjects. RESULTS Mean change in anisocoria was not significantly different among groups at any of the measurement time points. Mean percent change in diameter of the treated eyes showed a trend toward faster maximum dilatation in the AD groups, but change in pupillary measurements did not identify individuals with AD. CONCLUSIONS Pupillary response to dilute tropicamide did not effectively distinguish individual patients with AD from young or older control subjects.
D N Loupe, and
N J Newman, and
R C Green, and
M J Lynn, and
K K WIlliams, and
T C Geis, and
H F Edelhauser
June 1996,
Acta ophthalmologica Scandinavica,
D N Loupe, and
N J Newman, and
R C Green, and
M J Lynn, and
K K WIlliams, and
T C Geis, and
H F Edelhauser
March 1997,
Experimental neurology,
D N Loupe, and
N J Newman, and
R C Green, and
M J Lynn, and
K K WIlliams, and
T C Geis, and
H F Edelhauser
March 1996,
British journal of clinical pharmacology,
D N Loupe, and
N J Newman, and
R C Green, and
M J Lynn, and
K K WIlliams, and
T C Geis, and
H F Edelhauser
October 2003,
Neurobiology of aging,
D N Loupe, and
N J Newman, and
R C Green, and
M J Lynn, and
K K WIlliams, and
T C Geis, and
H F Edelhauser
May 1997,
The American journal of psychiatry,
D N Loupe, and
N J Newman, and
R C Green, and
M J Lynn, and
K K WIlliams, and
T C Geis, and
H F Edelhauser
May 1988,
Annals of internal medicine,
D N Loupe, and
N J Newman, and
R C Green, and
M J Lynn, and
K K WIlliams, and
T C Geis, and
H F Edelhauser
February 1997,
Archives of neurology,
D N Loupe, and
N J Newman, and
R C Green, and
M J Lynn, and
K K WIlliams, and
T C Geis, and
H F Edelhauser
November 1968,
American journal of ophthalmology,
D N Loupe, and
N J Newman, and
R C Green, and
M J Lynn, and
K K WIlliams, and
T C Geis, and
H F Edelhauser
July 1997,
Archives of neurology,
D N Loupe, and
N J Newman, and
R C Green, and
M J Lynn, and
K K WIlliams, and
T C Geis, and
H F Edelhauser
January 1999,
Functional neurology,
