Biomaterial Database

Impact of Ovabloc intratubal polymer on the morphology of the fallopian tube. 1995

G van der Leij, and C van Krimpen

Department of Gynaecology and Obstetrics, Schieland Hospital, The Netherlands.

Treatment of the fallopian tubes by Ovabloc silicone intratubal polymer (ITP; Dow Corning silastic 382 Medical-Grade Elastomer) is used for permanent female contraception. Studies on animals show minor structural changes in the tubal epithelial lining caused by the ITP and suggest reversibility of tubal integrity after removal of the polymer. The aim of this study was to examine the impact of the ITP on the human tubal epithelial lining. From 13 patients treated with ITP, 23 fallopian tubes were studied by light microscopy and transmission electron microscopy. The examined 19 isthmical and 10 ampullary parts show marked structural changes. In the isthmical parts of the fallopian tubes, cellular and ciliary changes develop immediately after insertion of the silicone polymer. As for the ampullary parts, the cellular and ciliary changes are related to the ITP exposure time. The changes in the isthmus and ampulla are persistent for at least 15 months after removal of the ITP. It is not known whether the effects are reversible.

UI	MeSH Term	Description	Entries
D008854	Microscopy, Electron	Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.	Electron Microscopy
D002923	Cilia	Populations of thin, motile processes found covering the surface of ciliates (CILIOPHORA) or the free surface of the cells making up ciliated EPITHELIUM. Each cilium arises from a basic granule in the superficial layer of CYTOPLASM. The movement of cilia propels ciliates through the liquid in which they live. The movement of cilia on a ciliated epithelium serves to propel a surface layer of mucus or fluid. (King & Stansfield, A Dictionary of Genetics, 4th ed)	Motile Cilia,Motile Cilium,Nodal Cilia,Nodal Cilium,Primary Cilia,Primary Cilium,Cilium,Cilia, Motile,Cilia, Nodal,Cilia, Primary,Cilium, Motile,Cilium, Nodal,Cilium, Primary
D005187	Fallopian Tubes	A pair of highly specialized canals extending from the UTERUS to its corresponding OVARY. They provide the means for OVUM transport from the ovaries and they are the site of the ovum's final maturation and FERTILIZATION. The fallopian tube consists of an interstitium, an isthmus, an ampulla, an infundibulum, and fimbriae. Its wall consists of three layers: serous, muscular, and an internal mucosal layer lined with both ciliated and secretory cells.	Oviducts, Mammalian,Salpinges, Uterine,Salpinx, Uterine,Uterine Salpinges,Uterine Salpinx,Fallopian Tube,Uterine Tubes,Mammalian Oviduct,Mammalian Oviducts,Oviduct, Mammalian,Tube, Fallopian,Tube, Uterine,Tubes, Fallopian,Tubes, Uterine,Uterine Tube
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001706	Biopsy	Removal and pathologic examination of specimens from the living body.	Biopsies
D012189	Retrospective Studies	Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.	Retrospective Study,Studies, Retrospective,Study, Retrospective
D012826	Silicone Elastomers	Polymers of silicone that are formed by crosslinking and treatment with amorphous silica to increase strength. They have properties similar to vulcanized natural rubber, in that they stretch under tension, retract rapidly, and fully recover to their original dimensions upon release. They are used in the encapsulation of surgical membranes and implants.	Elastomers, Silicone,Rubber Silicone,Silicone Rubber,Elastosil,Microfil,SE-30,Elastosils,Microfils,SE 30,SE30,Silicone Elastomer
D013246	Sterilization, Tubal	Procedures that render the female sterile by interrupting the flow in the FALLOPIAN TUBE. These procedures generally are surgical, and may also use chemicals or physical means.	Ligation, Tubal,Tubal Ligation,Aldridge Procedure,Chemical Tubal Occlusion,Cooke Method,Cornual Coagulation,Fimbriectomy,Irving Method,Kroener Fimbriectomy,Kroener Method,Madlener Method,Nonchemical Tubal Occlusion,Occlusion, Chemical Tubal,Occlusion, Nonchemical Tubal,Pomeroy Method,Pomeroy Sterilization,Tubal Occlusion,Tubal Occlusion, Chemical,Tubal Occlusion, Nonchemical,Tubal Rings,Uchida Method,Chemical Tubal Occlusions,Coagulations, Cornual,Cornual Coagulations,Fimbriectomies,Fimbriectomy, Kroener,Ligations, Tubal,Nonchemical Tubal Occlusions,Ring, Tubal,Rings, Tubal,Sterilization, Pomeroy,Sterilizations, Tubal,Tubal Ligations,Tubal Occlusions,Tubal Occlusions, Chemical,Tubal Occlusions, Nonchemical,Tubal Ring,Tubal Sterilization,Tubal Sterilizations