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Fas ligand (FasL, Apo-1L) is a member of the tumor necrosis factor protein family and binding to its receptor (Fas, Apo-1, CD95) triggers cell death through apoptosis. Ligand expression is restricted to cells with known cytolytic activity and found on hematopoietic cells of the T cell and natural killer lineage. Here we provide evidence that B lymphocytes can express FasL. Flow cytometric analysis revealed that FasL is expressed on the surface of B cells upon stimulation with either lipopolysaccharide or phorbol 12-myristate 13-acetate/ionomycin. FasL expression on activated B cells was confirmed by western blot and reverse transcriptase polymerase chain reaction analysis. FasL on B cells is functional since lipopolysaccharide-activated B lymphocytes derived from wild type, but not from gld mutant mice, were able to kill Fas-sensitive target cells. Our data suggest that the Fas system may contribute to the control of B cell homeostasis.
M Hahne, and
T Renno, and
M Schroeter, and
M Irmler, and
L French, and
T Bornard, and
H R MacDonald, and
J Tschopp
January 2014,
The Annals of thoracic surgery,
M Hahne, and
T Renno, and
M Schroeter, and
M Irmler, and
L French, and
T Bornard, and
H R MacDonald, and
J Tschopp
July 1998,
Research communications in molecular pathology and pharmacology,
M Hahne, and
T Renno, and
M Schroeter, and
M Irmler, and
L French, and
T Bornard, and
H R MacDonald, and
J Tschopp
September 1997,
Transplantation proceedings,
M Hahne, and
T Renno, and
M Schroeter, and
M Irmler, and
L French, and
T Bornard, and
H R MacDonald, and
J Tschopp
October 2007,
Stem cells (Dayton, Ohio),
M Hahne, and
T Renno, and
M Schroeter, and
M Irmler, and
L French, and
T Bornard, and
H R MacDonald, and
J Tschopp
March 1997,
Cancer research,
M Hahne, and
T Renno, and
M Schroeter, and
M Irmler, and
L French, and
T Bornard, and
H R MacDonald, and
J Tschopp
October 1999,
Leukemia research,
M Hahne, and
T Renno, and
M Schroeter, and
M Irmler, and
L French, and
T Bornard, and
H R MacDonald, and
J Tschopp
December 1999,
Hepatology (Baltimore, Md.),
M Hahne, and
T Renno, and
M Schroeter, and
M Irmler, and
L French, and
T Bornard, and
H R MacDonald, and
J Tschopp
April 1994,
European journal of immunology,
M Hahne, and
T Renno, and
M Schroeter, and
M Irmler, and
L French, and
T Bornard, and
H R MacDonald, and
J Tschopp
March 2000,
Scandinavian journal of immunology,
M Hahne, and
T Renno, and
M Schroeter, and
M Irmler, and
L French, and
T Bornard, and
H R MacDonald, and
J Tschopp
January 2001,
Journal of leukocyte biology,
