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The rat liver glucorcorticoid receptor has been activated using three procedures: heat, gel filtration, and dilution. With time after heat activation the steroid--receptor complex loses its capacity to bind to DNA--cellulose, while receptor activated by Sephadex G-25 and by dilution maintains DNA--cellulose binding capacity. The rates of steroid dissociation from nonactivated and activated receptor and essentially identical. However, nonactivated receptor is capable of rebinding steroid, while activated receptor has a reduced capacity to rebind steroid. The results of the gel filtration and dilution studies suggest that a low-molecular-weight factor(s) exists in rat liver cytosol which is involved in the process of activation.
J A Goidl, and
M H Cake, and
K P Dolan, and
L G Parchman, and
G Litwack
August 1983,
European journal of biochemistry,
J A Goidl, and
M H Cake, and
K P Dolan, and
L G Parchman, and
G Litwack
October 1982,
Physiological reviews,
J A Goidl, and
M H Cake, and
K P Dolan, and
L G Parchman, and
G Litwack
January 1982,
Journal of cellular biochemistry,
J A Goidl, and
M H Cake, and
K P Dolan, and
L G Parchman, and
G Litwack
May 1984,
Biochemical and biophysical research communications,
J A Goidl, and
M H Cake, and
K P Dolan, and
L G Parchman, and
G Litwack
December 1987,
Journal of steroid biochemistry,
J A Goidl, and
M H Cake, and
K P Dolan, and
L G Parchman, and
G Litwack
December 1985,
Biochemical and biophysical research communications,
J A Goidl, and
M H Cake, and
K P Dolan, and
L G Parchman, and
G Litwack
September 1980,
The Biochemical journal,
J A Goidl, and
M H Cake, and
K P Dolan, and
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G Litwack
August 1980,
Biochimica et biophysica acta,
J A Goidl, and
M H Cake, and
K P Dolan, and
L G Parchman, and
G Litwack
June 1983,
Journal of steroid biochemistry,
J A Goidl, and
M H Cake, and
K P Dolan, and
L G Parchman, and
G Litwack
May 1980,
The Journal of biological chemistry,
