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OBJECTIVE To determine the published incidence of adult respiratory distress syndrome (ARDS) as well as the clinical evidence supporting a casual association between ARDS and its major risk factors. METHODS The National Library of Medicine MEDLINE database and the bibliographies of selected articles. METHODS Clinical studies were selected from the English literature, if they pertained to either the incidence of ARDS or its association with one or more commonly identified risk factors. METHODS All relevant studies identified by the search were evaluated for strength of design, and risk factors were scored according to established criteria for the strength of causation. RESULTS A total of 83 articles were considered relevant: six of incidence and 77 on risk factors. Only 49% of the 83 articles provided a definition of ARDS; a definition of risk factors was given in 64%, and 23% had no definition for either ARDS or risk factors. The published, population-based incidence of ARDS ranges from 1.5 to 5.3/10(5) population/yr. The strongest clinical evidence supporting a cause-effect relationship was identified for sepsis, aspiration, trauma, and multiple transfusions. The weakest clinical evidence was identified for disseminated intravascular coagulation. The following study types were represented by the 77 articles on risk factors: observational case-series (56%); cohorts (23%); case-controls (12%); nonrandomized clinical trials (5%); and randomized clinical trials (3%). Only a single study reported an odds ratio. CONCLUSIONS The significant variation in the incidence of ARDS is attributed to differences in the type and strength of study designs, as well as definitions or ARDS. While a substantial body of evidence exists concerning a casual role of ARDS risk factors, such as sepsis, aspiration, and trauma, > 60% of clinical studies employed weak designs. The lack of reproducible definitions for ARDS or its potential risk factors in 49% of studies raises concerns about the validity of the conclusions of these studies regarding the association between ARDS and the supposed risk factors.
B G Garber, and
P C Hébert, and
J D Yelle, and
R V Hodder, and
J McGowan
January 1994,
Intensive care medicine,
B G Garber, and
P C Hébert, and
J D Yelle, and
R V Hodder, and
J McGowan
September 1989,
The American review of respiratory disease,
B G Garber, and
P C Hébert, and
J D Yelle, and
R V Hodder, and
J McGowan
July 2019,
Journal of pediatric surgery,
B G Garber, and
P C Hébert, and
J D Yelle, and
R V Hodder, and
J McGowan
September 1992,
British journal of rheumatology,
B G Garber, and
P C Hébert, and
J D Yelle, and
R V Hodder, and
J McGowan
March 1992,
Anaesthesia,
B G Garber, and
P C Hébert, and
J D Yelle, and
R V Hodder, and
J McGowan
September 2010,
Zhonghua yi xue za zhi,
B G Garber, and
P C Hébert, and
J D Yelle, and
R V Hodder, and
J McGowan
May 1983,
Annals of internal medicine,
B G Garber, and
P C Hébert, and
J D Yelle, and
R V Hodder, and
J McGowan
May 2003,
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP,
B G Garber, and
P C Hébert, and
J D Yelle, and
R V Hodder, and
J McGowan
February 1991,
American journal of surgery,
B G Garber, and
P C Hébert, and
J D Yelle, and
R V Hodder, and
J McGowan
October 1975,
Masui. The Japanese journal of anesthesiology,
