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The effect of bilateral fetal or maternal nephrectomy on basal and diuretic-stimulated plasma renin activity (Pra) was examined in 9 chronically catheterized Dorset sheep. After fetal nephrectomy, there was an initial rapid decrease in fetal PRA with t1/2 of 42-84 min, followed by a slower decrement with 1/2 350-720 min. There was no change in maternal PRA during this period. Similarly, after maternal nephrectomy, the decrease in maternal PRA had two exponential components and there was no associated change in fetal PRA. These data, and the maternal and fetal PRA responses to intravenous furosemide, have demonstrated that renin does not cross the sheep placenta and that fetal PRA is independent of the maternal PRA level.
G K Oakes, and
A R Fleischman, and
K J Catt, and
R A Chez
January 1976,
Urologiia i nefrologiia,
G K Oakes, and
A R Fleischman, and
K J Catt, and
R A Chez
May 1979,
American journal of obstetrics and gynecology,
G K Oakes, and
A R Fleischman, and
K J Catt, and
R A Chez
February 1977,
The Anatomical record,
G K Oakes, and
A R Fleischman, and
K J Catt, and
R A Chez
July 1988,
Pediatric research,
G K Oakes, and
A R Fleischman, and
K J Catt, and
R A Chez
October 1979,
Journal of developmental physiology,
G K Oakes, and
A R Fleischman, and
K J Catt, and
R A Chez
August 1978,
Obstetrics and gynecology,
G K Oakes, and
A R Fleischman, and
K J Catt, and
R A Chez
January 1990,
Journal of perinatal medicine,
G K Oakes, and
A R Fleischman, and
K J Catt, and
R A Chez
June 1985,
British journal of obstetrics and gynaecology,
G K Oakes, and
A R Fleischman, and
K J Catt, and
R A Chez
January 1971,
Experientia,
G K Oakes, and
A R Fleischman, and
K J Catt, and
R A Chez
November 1983,
American journal of obstetrics and gynecology,
