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Hepatic uptake and biliary excretion of a bile salt analog : glycodihydrofusidate. 1977

J C Montet, and A Gerolami, and J P Durbec, and C Crotte, and A M Montet, and J C Hauton

Glyco-24, 25-dihydrofusidate is efficiently excreted in the bile by the liver. This compound partially inhibits hepatobiliary transport of bile salts and bilirubin. In order to determine if bile salts and glycodihydrofusidate share common pathways at the hepatocyte level, we studied the effect of sodium dehydrocholate on the blood clearance of glycodihydrofusidate. Two groups of rats were perfused, controls with 0.15M NaCl, and test animals with 10 micronmol + min-(1) + kg(1) of dehydrocholate; both groups received 1 micronCi of 14C-glycodihydrofusidate intravenously. Carotid blood was removed every minute and the disappearance of radioactivity from the blood was monitored. The results are consisgent with a theoretical model of two compartments. The experimental curves were fit to the sum of exponentials.

UI MeSH Term Description Entries
D007700 Kinetics The rate dynamics in chemical or physical systems.
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008297 Male Males
D008954 Models, Biological Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment. Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D003685 Dehydrocholic Acid A semisynthetic bile acid made from cholic acid. It is used as a cholagogue, hydrocholeretic, diuretic, and as a diagnostic aid. Dehydrocholate,Ketocholanic Acid,Triketocholanic Acid,Trioxocholate,(5beta)-3,7,12-Trioxocholan-24-oic Acid,Atrocholin,Cholan-HMB,Chologon,Decholin,Dehydrocholic Acid, Lithium Salt,Dehydrocholic Acid, Magnesium Salt,Dehydrocholic Acid, Potassium Salt,Dehydrocholic Acid, Sodium Salt,Sodium Dehydrocholate,Cholan HMB,CholanHMB,Dehydrocholate, Sodium
D004347 Drug Interactions The action of a drug that may affect the activity, metabolism, or toxicity of another drug. Drug Interaction,Interaction, Drug,Interactions, Drug
D005672 Fusidic Acid An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting translocation during protein synthesis. Fucithalmic,Fusidate Sodium,Fusidic Acid, Sodium Salt,Fusidin,Silver Fusidate,Sodium Fusidate,Stanicide,Acid, Fusidic,Fusidate, Silver,Fusidate, Sodium,Sodium, Fusidate
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001646 Bile An emulsifying agent produced in the LIVER and secreted into the DUODENUM. Its composition includes BILE ACIDS AND SALTS; CHOLESTEROL; and ELECTROLYTES. It aids DIGESTION of fats in the duodenum. Biliary Sludge,Sludge, Biliary
D001647 Bile Acids and Salts Steroid acids and salts. The primary bile acids are derived from cholesterol in the liver and usually conjugated with glycine or taurine. The secondary bile acids are further modified by bacteria in the intestine. They play an important role in the digestion and absorption of fat. They have also been used pharmacologically, especially in the treatment of gallstones. Bile Acid,Bile Salt,Bile Salts,Bile Acids,Acid, Bile,Acids, Bile,Salt, Bile,Salts, Bile

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