-transparent.png){kind=logo}
A subchronic toxicity study with L-isoleucine was conducted using F344 rats. Groups of 10 rats of each sex were given diet containing 0, 1.25, 2.5, 5.0, or 8.0% L-isoleucine for 13 wk. No treatment-related effects were observed in terms of body weight change, food consumption or hematology. In both sexes given 8.0% L-isoleucine, increased or a tendency for increased urine volume and relative kidney weights were observed. Furthermore, the high-dose L-isoleucine treatment brought about an elevation of urinary pH and variations in serum electrolytes. However, histopathological alterations related to these changes were not observed in any organs of either sex. In conclusion, the present study demonstrated that L-isoleucine possessed minimal toxicity at dietary levels of 5.0% and 8.0%, while it did not exert any adverse affects at a dietary level of 2.5% or less.
M Kawabe, and
Y Takesada, and
S Tamano, and
A Hagiwara, and
N Ito, and
T Shirai
January 1994,
Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences,
M Kawabe, and
Y Takesada, and
S Tamano, and
A Hagiwara, and
N Ito, and
T Shirai
January 1994,
Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences,
M Kawabe, and
Y Takesada, and
S Tamano, and
A Hagiwara, and
N Ito, and
T Shirai
January 1991,
Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences,
M Kawabe, and
Y Takesada, and
S Tamano, and
A Hagiwara, and
N Ito, and
T Shirai
January 1991,
Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences,
M Kawabe, and
Y Takesada, and
S Tamano, and
A Hagiwara, and
N Ito, and
T Shirai
October 2021,
Journal of toxicologic pathology,
M Kawabe, and
Y Takesada, and
S Tamano, and
A Hagiwara, and
N Ito, and
T Shirai
January 2006,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
M Kawabe, and
Y Takesada, and
S Tamano, and
A Hagiwara, and
N Ito, and
T Shirai
August 2006,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
M Kawabe, and
Y Takesada, and
S Tamano, and
A Hagiwara, and
N Ito, and
T Shirai
January 1989,
Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences,
M Kawabe, and
Y Takesada, and
S Tamano, and
A Hagiwara, and
N Ito, and
T Shirai
May 1992,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
M Kawabe, and
Y Takesada, and
S Tamano, and
A Hagiwara, and
N Ito, and
T Shirai
January 1990,
Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences,
