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OBJECTIVE To test the reliability of creatinine clearance in children on peritoneal dialysis (PD). METHODS Longitudinal, case-controlled. METHODS Routine clinic visits at the pediatric dialysis unit of the Universitätskinderklinik of Vienna. METHODS Eleven children (2-13 years, 10-55 kg) with end-stage renal disease on PD. METHODS Creatinine clearance (CCr) was determined by measuring creatinine excretion (ECr) over 24 hours in both dialysate and urine. Each child had three to five separate measurements of their CCr. At the same time we also calculated the Schwartz formula clearance from the patient's height and serum creatinine, using a modified correlate. METHODS Reliability of CCr was assessed by two approaches. First, we compared each serial measurement with the mean value for each patient and thereby assessed the "intramethodical" variability. Second, we compared each CCr with the simultaneous formula clearance and assessed the "intermethodical" disagreement. RESULTS Twenty-seven percent of the measurements of CCr were classified as unreliable based on a comparison with the mean value for each patient. Reliability was closely correlated with residual renal function (p < 0.01); only 12% of the measurements in the anuric patients were classified as unreliable (vs 31% in the patients with residual renal function). The simultaneous formula clearance was less variable than the CCr. The formula clearance had a sensitivity of 93% and a specificity of 60% for detecting unreliable values of CCr. CONCLUSIONS Estimation of total CCr is unreliable in pediatric patients on PD. A simultaneous formula clearance can be used to detect which values are unreliable.
C Aufricht, and
E Kitzmüller, and
M A Lothaller, and
T Müller, and
R Birnbacher, and
E Balzar, and
L Greenbaum
January 1992,
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C Aufricht, and
E Kitzmüller, and
M A Lothaller, and
T Müller, and
R Birnbacher, and
E Balzar, and
L Greenbaum
January 1992,
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis,
C Aufricht, and
E Kitzmüller, and
M A Lothaller, and
T Müller, and
R Birnbacher, and
E Balzar, and
L Greenbaum
December 2010,
International urology and nephrology,
C Aufricht, and
E Kitzmüller, and
M A Lothaller, and
T Müller, and
R Birnbacher, and
E Balzar, and
L Greenbaum
January 2010,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
C Aufricht, and
E Kitzmüller, and
M A Lothaller, and
T Müller, and
R Birnbacher, and
E Balzar, and
L Greenbaum
October 2020,
BMC nephrology,
C Aufricht, and
E Kitzmüller, and
M A Lothaller, and
T Müller, and
R Birnbacher, and
E Balzar, and
L Greenbaum
January 1997,
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis,
C Aufricht, and
E Kitzmüller, and
M A Lothaller, and
T Müller, and
R Birnbacher, and
E Balzar, and
L Greenbaum
November 2000,
American journal of kidney diseases : the official journal of the National Kidney Foundation,
C Aufricht, and
E Kitzmüller, and
M A Lothaller, and
T Müller, and
R Birnbacher, and
E Balzar, and
L Greenbaum
January 1997,
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis,
C Aufricht, and
E Kitzmüller, and
M A Lothaller, and
T Müller, and
R Birnbacher, and
E Balzar, and
L Greenbaum
January 2001,
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis,
C Aufricht, and
E Kitzmüller, and
M A Lothaller, and
T Müller, and
R Birnbacher, and
E Balzar, and
L Greenbaum
January 1996,
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis,
