-transparent.png){kind=logo}
Hexachlorobenzene (HCB) is an important environmental contaminant derived mainly from industrial and agricultural sources. It is carcinogenic in mice, rats and hamsters. It has now been studied in a medium-term bioassay for carcinogenicity based on the induction of preneoplastic lesions in the liver. We report here that the bioassay can rapidly detect carcinogenic doses of HCB and that there is a clear dose-response relationship. At the lowest dose of HCB administered, the incidence of preneoplastic lesions in the liver was no different from that in controls.
Related Publications
R Cabral, and
T Hoshiya, and
K Hakoi, and
R Hasegawa, and
N Ito
February 2000,
Toxicological sciences : an official journal of the Society of Toxicology,
R Cabral, and
T Hoshiya, and
K Hakoi, and
R Hasegawa, and
N Ito
July 1998,
Cancer letters,
R Cabral, and
T Hoshiya, and
K Hakoi, and
R Hasegawa, and
N Ito
August 1992,
Japanese journal of cancer research : Gann,
R Cabral, and
T Hoshiya, and
K Hakoi, and
R Hasegawa, and
N Ito
January 1991,
Progress in experimental tumor research,
R Cabral, and
T Hoshiya, and
K Hakoi, and
R Hasegawa, and
N Ito
October 2022,
Journal of toxicologic pathology,
R Cabral, and
T Hoshiya, and
K Hakoi, and
R Hasegawa, and
N Ito
March 2001,
Cancer research,
R Cabral, and
T Hoshiya, and
K Hakoi, and
R Hasegawa, and
N Ito
January 1997,
Toxicologic pathology,
R Cabral, and
T Hoshiya, and
K Hakoi, and
R Hasegawa, and
N Ito
May 1978,
Cancer letters,
R Cabral, and
T Hoshiya, and
K Hakoi, and
R Hasegawa, and
N Ito
April 1996,
Journal of toxicology and environmental health,
R Cabral, and
T Hoshiya, and
K Hakoi, and
R Hasegawa, and
N Ito
January 1999,
Japanese journal of cancer research : Gann,
