BIOMAT Database Logo BIOMAT Database Logo

Liver endogenous antioxidant defenses in mice fed AIN-76A diet and infected with murine AIDS. 1996

L H Chen, and S Xi, and D A Cohen
Department of Nutrition and Food Science, University of Kentucky, Lexington, 40506-0054, USA.

The effects of murine AIDS infection on endogenous antioxidant defenses in mice fed the AIN-76A liquid diet were investigated. C57BL/6 female mice were divided into 2 groups: one group was injected interperitoneally with LP-BM5 murine retrovirus (MAIDS) stock, and the other group served as the non-infected control. Two weeks after the infection, the mice were killed and livers were excised for biochemical analysis of the antioxidant defenses. Liver reduced glutathione (GSH) levels and activities of both cytosolic superoxide dismutase (SOD) and mitochondrial SOD were significantly depressed by MAIDS infection. Activities of glutathione reductase (GR) selenium (Se)-dependent glutathione peroxidase (GPx), catalase and glutathione-S-transferase (GST) toward 1-chloro-2,4-dinitrobenzene (CDNB) were not affected by MAIDS infection. A previous study by this laboratory using the Lieber-DeCarli (L-D) all purpose liquid diet caused a decline in total SOD activity and GPx activity, but not GSH levels. The results suggest that MAIDS infection depresses liver antioxidant defenses; however, MAIDS infection of mice fed the AID-76A liquid diet depresses different liver antioxidant defense parameters when compared to those of the mice fed the L-D all purpose liquid diet.

UI MeSH Term Description Entries
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D008815 Mice, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation. Inbred Mouse Strains,Inbred Strain of Mice,Inbred Strain of Mouse,Inbred Strains of Mice,Mouse, Inbred Strain,Inbred Mouse Strain,Mouse Inbred Strain,Mouse Inbred Strains,Mouse Strain, Inbred,Mouse Strains, Inbred,Strain, Inbred Mouse,Strains, Inbred Mouse
D002374 Catalase An oxidoreductase that catalyzes the conversion of HYDROGEN PEROXIDE to water and oxygen. It is present in many animal cells. A deficiency of this enzyme results in ACATALASIA. Catalase A,Catalase T,Manganese Catalase,Mn Catalase
D004032 Diet Regular course of eating and drinking adopted by a person or animal. Diets
D004137 Dinitrochlorobenzene A skin irritant that may cause dermatitis of both primary and allergic types. Contact sensitization with DNCB has been used as a measure of cellular immunity. DNCB is also used as a reagent for the detection and determination of pyridine compounds. 1-Chloro-2,4-Dinitrobenzene,2,4-Dinitrochlorobenzene,Benzene, 1-Chloro-2,4-Dinitro-,Chlorodinitrobenzene,DNCB,1 Chloro 2,4 Dinitrobenzene,2,4 Dinitrochlorobenzene
D005260 Female Females
D005609 Free Radicals Highly reactive molecules with an unsatisfied electron valence pair. Free radicals are produced in both normal and pathological processes. Free radicals include reactive oxygen and nitrogen species (RONS). They are proven or suspected agents of tissue damage in a wide variety of circumstances including radiation, damage from environment chemicals, and aging. Natural and pharmacological prevention of free radical damage is being actively investigated. Free Radical
D005978 Glutathione A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides. Reduced Glutathione,gamma-L-Glu-L-Cys-Gly,gamma-L-Glutamyl-L-Cysteinylglycine,Glutathione, Reduced,gamma L Glu L Cys Gly,gamma L Glutamyl L Cysteinylglycine
D005980 Glutathione Reductase Catalyzes the oxidation of GLUTATHIONE to GLUTATHIONE DISULFIDE in the presence of NADP+. Deficiency in the enzyme is associated with HEMOLYTIC ANEMIA. Formerly listed as EC 1.6.4.2. Glutathione-Disulfide Reductase,Reductase, Glutathione,Reductase, Glutathione-Disulfide

Related Publications

L H Chen, and S Xi, and D A Cohen
Increased incidence of spontaneous and 2-acetylaminofluorene-induced liver and bladder tumors in B6C3F1 mice fed AIN-76A diet versus NIH-07 diet.
January 1991, Fundamental and applied toxicology : official journal of the Society of Toxicology,
L H Chen, and S Xi, and D A Cohen
Development of hepatic lesions in male Fischer-344 rats fed AIN-76A purified diet.
January 1982, Toxicology and applied pharmacology,
L H Chen, and S Xi, and D A Cohen
Mineral interactions in rats fed AIN-76A diets with excess calcium.
March 1994, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
L H Chen, and S Xi, and D A Cohen
Lack of bladder tumor promoting activity in rats fed sodium saccharin in AIN-76A diet.
April 1991, Cancer research,
L H Chen, and S Xi, and D A Cohen
Effects of diet type on incidence of spontaneous and 2-acetylaminofluorene-induced liver and bladder tumors in BALB/c mice fed AIN-76A diet versus NIH-07 diet.
February 1992, Fundamental and applied toxicology : official journal of the Society of Toxicology,
L H Chen, and S Xi, and D A Cohen
Nutritional and pathological changes in male and female rats fed modifications of the AIN-76A diet.
March 1989, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
L H Chen, and S Xi, and D A Cohen
Components of the AIN-93 diets as improvements in the AIN-76A diet.
May 1997, The Journal of nutrition,
L H Chen, and S Xi, and D A Cohen
Foetal development in rats fed AIN-76A diets supplemented with excess calcium.
December 1993, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
L H Chen, and S Xi, and D A Cohen
Endogenous antioxidant defenses in neonates.
January 1986, Journal of free radicals in biology & medicine,
L H Chen, and S Xi, and D A Cohen
Comparison of AIN-76A and AIN-93G diets: a 13-week study in rats.
April 2001, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
Copied contents to your clipboard!