Biomaterial Database

Oral focal acantholytic dyskeratosis induced in sialoadenectomized rats painted orally with the carcinogen 4-nitroquinoline N-oxide. 1993

C M Navarro, and O Paes de Almeida, and C Scully

Department of Oral Pathology, Faculty of Odontology of Piracicaba-UNICAMP, Piracicaba, SP, Brazil.

This study examines the effects of xerostomia on the development of mucosal changes proceeding carcinoma in rats painted orally with 4-nitroquinoline N-oxide (4NQO). Sialoadenectomy enhanced the incidence of focal acantholytic dyskeratosis (FAD) on the palate and tongue of rats painted on the palate with 0.5% 4NQO three times weekly. At one month, no changes were observed. After two months of painting with 4NQO, sialoadenectomized rats, but not controls, had FAD. After three months, FAD was seen in both test and control groups, but the incidence of FAD was higher in the test group and seen more on the palate than on the tongue of xerostomic animals. Neither test nor control animals developed carcinoma within this study period.

UI	MeSH Term	Description	Entries
D007642	Keratosis	Any horny growth such as a wart or callus.	Keratoderma Blennorrhagicum,Keratoma,Keratosis Blennorrhagica,Blennorrhagica, Keratosis,Blennorrhagicas, Keratosis,Blennorrhagicum, Keratoderma,Blennorrhagicums, Keratoderma,Keratoderma Blennorrhagicums,Keratomas,Keratoses,Keratosis Blennorrhagicas
D010159	Palate	The structure that forms the roof of the mouth. It consists of the anterior hard palate (PALATE, HARD) and the posterior soft palate (PALATE, SOFT).	Incisive Papilla,Incisive Papillas,Palates,Papilla, Incisive,Papillas, Incisive
D011230	Precancerous Conditions	Pathological conditions that tend eventually to become malignant.	Preneoplastic Conditions,Condition, Preneoplastic,Conditions, Preneoplastic,Preneoplastic Condition,Condition, Precancerous,Conditions, Precancerous,Precancerous Condition
D002273	Carcinogens	Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.	Carcinogen,Oncogen,Oncogens,Tumor Initiator,Tumor Initiators,Tumor Promoter,Tumor Promoters,Initiator, Tumor,Initiators, Tumor,Promoter, Tumor,Promoters, Tumor
D000051	Acantholysis	Separation of the prickle cells of the stratum spinosum of the epidermis, resulting in atrophy of the prickle cell layer. It is seen in diseases such as pemphigus vulgaris (see PEMPHIGUS) and DARIER DISEASE.	Acantholyses
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014059	Tongue	A muscular organ in the mouth that is covered with pink tissue called mucosa, tiny bumps called papillae, and thousands of taste buds. The tongue is anchored to the mouth and is vital for chewing, swallowing, and for speech.	Tongues
D014987	Xerostomia	Decreased salivary flow.	Asialia,Hyposalivation,Mouth Dryness,Asialias,Dryness, Mouth,Hyposalivations,Xerostomias
D015112	4-Nitroquinoline-1-oxide	A potent mutagen and carcinogen. This compound and its metabolite 4-HYDROXYAMINOQUINOLINE-1-OXIDE bind to nucleic acids. It inactivates bacteria but not bacteriophage.	4-Nitroquinoline-N-oxide,4 Nitroquinoline 1 oxide,4 Nitroquinoline N oxide
D017208	Rats, Wistar	A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.	Wistar Rat,Rat, Wistar,Wistar Rats