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The objective of this study was to determine the effects of repetitive ischemia on myocardial oxygen tension (pO2), consumption, and delivery in crystalloid normoperfused (perfusion pressure>70 mmHg) and hypoperfused (perfusion pressure approximately 50 mmHg) constant flow isolated rat hearts. EPR oximetry with lithium phthalocyanine was used to measure myocardial pO2. Baseline myocardial pO2 (means +/- SE) was 185 +/- 13 mmHg (normoperfused) and 162 +/- 14 mmHg (hypoperfused). Myocardial pO2 fell to < 1 mmHg during no-flow ischemia. After recovery from repetitive ischemia, myocardial pO2 and coronary resistance increased significantly in all hearts; oxygen consumption and left ventricle work decreased in normoperfused hearts, although not significantly compared with controls, and did not change significantly in hypoperfused hearts. Increased myocardial pO2 in the normoperfused group may be due to decreased oxygen consumption and/or increased local delivery, while increased myocardial pO2 in the hypoperfused hearts is due to increased local oxygen delivery.
B J Friedman, and
O Y Grinberg, and
K A Isaacs, and
E K Ruuge, and
H M Swartz
January 1987,
Archivio italiano di anatomia e di embriologia. Italian journal of anatomy and embryology,
B J Friedman, and
O Y Grinberg, and
K A Isaacs, and
E K Ruuge, and
H M Swartz
October 2002,
The Journal of thoracic and cardiovascular surgery,
B J Friedman, and
O Y Grinberg, and
K A Isaacs, and
E K Ruuge, and
H M Swartz
April 1995,
Clinical nutrition (Edinburgh, Scotland),
B J Friedman, and
O Y Grinberg, and
K A Isaacs, and
E K Ruuge, and
H M Swartz
February 2003,
The Journal of cardiovascular surgery,
B J Friedman, and
O Y Grinberg, and
K A Isaacs, and
E K Ruuge, and
H M Swartz
December 1986,
Kokyu to junkan. Respiration & circulation,
B J Friedman, and
O Y Grinberg, and
K A Isaacs, and
E K Ruuge, and
H M Swartz
January 1983,
Basic research in cardiology,
B J Friedman, and
O Y Grinberg, and
K A Isaacs, and
E K Ruuge, and
H M Swartz
January 1990,
Heart and vessels,
B J Friedman, and
O Y Grinberg, and
K A Isaacs, and
E K Ruuge, and
H M Swartz
December 1996,
Canadian journal of physiology and pharmacology,
B J Friedman, and
O Y Grinberg, and
K A Isaacs, and
E K Ruuge, and
H M Swartz
May 1981,
The Journal of surgical research,
B J Friedman, and
O Y Grinberg, and
K A Isaacs, and
E K Ruuge, and
H M Swartz
April 1990,
Zhonghua xin xue guan bing za zhi,
