-transparent.png){kind=logo}
Microvascular compromise has been 1 of many factors implicated in the etiology of the cardiomyopathy associated with Chagas' disease. To further assess the effect of Trypanosoma cruzi infection on the microcirculation, we examined the cremaster microvascular model in CD-1 male mice infected with the Brazil strain at 20-25 days postinfection. There was a significant decrease in red cell velocity (Vrbc) in first and third-order arterioles and venules, which was reversed by verapamil treatment. Video recordings revealed a marked inflammatory response that was confirmed by transmission electron microscopy. A marked inflammatory response was not seen in verapamil-treated infected mice. Segmental vasospasm and dilatation was evident in the microvascular bed of infected mice. This was not seen in control or verapamil-treated mice. This model provides a readily accessible method to observe directly the effects of T. cruzi infection on the microcirculatory flow in vivo. In addition, it confirms and extends our previous observations regarding T. cruzi-associated microvascular spasm and underscores a role for verapamil, a calcium-channel blocker, in the amelioration of the Chagas' disease.
H B Tanowitz, and
D K Kaul, and
B Chen, and
S A Morris, and
S M Factor, and
L M Weiss, and
M Wittner
September 1998,
Acta tropica,
H B Tanowitz, and
D K Kaul, and
B Chen, and
S A Morris, and
S M Factor, and
L M Weiss, and
M Wittner
October 1996,
Experimental parasitology,
H B Tanowitz, and
D K Kaul, and
B Chen, and
S A Morris, and
S M Factor, and
L M Weiss, and
M Wittner
December 2022,
Scientific reports,
H B Tanowitz, and
D K Kaul, and
B Chen, and
S A Morris, and
S M Factor, and
L M Weiss, and
M Wittner
February 2017,
Parasitology research,
H B Tanowitz, and
D K Kaul, and
B Chen, and
S A Morris, and
S M Factor, and
L M Weiss, and
M Wittner
April 2013,
The Journal of antimicrobial chemotherapy,
H B Tanowitz, and
D K Kaul, and
B Chen, and
S A Morris, and
S M Factor, and
L M Weiss, and
M Wittner
January 2011,
Scandinavian journal of immunology,
H B Tanowitz, and
D K Kaul, and
B Chen, and
S A Morris, and
S M Factor, and
L M Weiss, and
M Wittner
January 1994,
Revista do Instituto de Medicina Tropical de Sao Paulo,
H B Tanowitz, and
D K Kaul, and
B Chen, and
S A Morris, and
S M Factor, and
L M Weiss, and
M Wittner
January 2020,
Laboratory animal research,
H B Tanowitz, and
D K Kaul, and
B Chen, and
S A Morris, and
S M Factor, and
L M Weiss, and
M Wittner
January 1984,
Cellular and molecular biology,
H B Tanowitz, and
D K Kaul, and
B Chen, and
S A Morris, and
S M Factor, and
L M Weiss, and
M Wittner
June 1994,
Experimental parasitology,
