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OBJECTIVE We evaluated urogenital anomalies in men with congenital absence of the vas deferens. METHODS A retrospective review was done of 104 subfertile men with congenital absence of the vas deferens (84 bilaterally and 20 unilaterally). RESULTS Of men with unilateral or bilateral congenital absence of the vas deferens 26 and 11%, respectively, had renal agenesis. Of men with unilateral congenital absence of the vas deferens and infertility 80% had genitourinary anamalies affecting the contralateral testis. No man with congenital absence of the vas deferens and renal anomalies had cystic fibrosis transmembrane-conductance regulator (CFTR) gene mutations detected. CONCLUSIONS Other urogenital anomalies are common for men with congenital absence of the vas deferens. CFTR gene mutations frequently contribute to maldevelopment of the vas deferens but vasal agenesis can occur without any evidence of CFTR defects. CFTR abnormalities are rarely detected in men with congenital absence of the vas deferens and renal anomalies.
P N Schlegel, and
D Shin, and
M Goldstein
August 1974,
Urology,
P N Schlegel, and
D Shin, and
M Goldstein
March 2001,
Human reproduction (Oxford, England),
P N Schlegel, and
D Shin, and
M Goldstein
November 1969,
British medical journal,
P N Schlegel, and
D Shin, and
M Goldstein
October 1969,
British medical journal,
P N Schlegel, and
D Shin, and
M Goldstein
December 1975,
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P N Schlegel, and
D Shin, and
M Goldstein
September 1982,
American family physician,
P N Schlegel, and
D Shin, and
M Goldstein
September 1971,
Indian journal of medical sciences,
P N Schlegel, and
D Shin, and
M Goldstein
April 1973,
The Journal of urology,
P N Schlegel, and
D Shin, and
M Goldstein
October 2004,
Zhonghua nan ke xue = National journal of andrology,
P N Schlegel, and
D Shin, and
M Goldstein
March 1965,
The Journal of urology,
