BIOMAT Database Logo BIOMAT Database Logo

Effect of hypertonic saline, amiloride, and cough on mucociliary clearance in patients with cystic fibrosis. 1996

M Robinson, and J A Regnis, and D L Bailey, and M King, and G J Bautovich, and P T Bye
Respiratory Investigation Unit, Royal Prince Alfred Hospital, Sydney, Australia.

In patients with cystic fibrosis (CF), dehydration of airway secretions leads to a decrease in mucociliary clearance (MCC). We examined the acute effect of MCC of a single administration by aerosolization of hypertonic saline (7%) (HS), amiloride (0.3% in 0.12% NaCl) (AML) and a combination of AML and HS (AML + HS) in 12 patients with CF using a radioaerosol technique. Isotonic saline [0.9%] (IS) was used as a control solution. As both the AML and HS solutions induced cough in some patients, the last nine patients studied also underwent a cough clearance day. This was to eliminate the possible confounding effect of cough on MCC measurement. Patients ranged from 18 to 28 yr (mean +/- SD, 22 +/- 3) with an FEV1 of 27 to 112% predicted (61 +/- 30%). Following deposition of the radioaerosol, baseline clearance was assessed for 30 min. This was followed by a 30-min intervention period. Assessment of post-intervention clearance for a further 30 min was then performed. Comparison of the amount of radioaerosol cleared from the right lung was made at 60 min (%C60) and 90 min (%C90) using repeated measures ANOVA. The percent cleared at 60 and 90 min was significantly increased with HS (%C60 = 26.5%, %C90 = 29.4%) and the combination of AML + HS (%C60 = 23.1%, %C90 = 27.4%) compared with both IS (%C60 = 14.7%, %C90 = 17.5%) and COUGH (%C60 = 18.0%, %C90 = 19.5%), p < 0.01. Inhalation of hypertonic saline is a potentially useful treatment in patients with cystic fibrosis.

UI MeSH Term Description Entries
D007552 Isotonic Solutions Solutions having the same osmotic pressure as blood serum, or another solution with which they are compared. (From Grant & Hackh's Chemical Dictionary, 5th ed & Dorland, 28th ed) Solutions, Isotonic
D008168 Lung Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood. Lungs
D008297 Male Males
D009079 Mucociliary Clearance A non-specific host defense mechanism that removes MUCUS and other material from the LUNGS by ciliary and secretory activity of the tracheobronchial submucosal glands. It is measured in vivo as mucus transfer, ciliary beat frequency, and clearance of radioactive tracers. Mucociliary Transport,Clearance, Mucociliary,Clearances, Mucociliary,Mucociliary Clearances,Mucociliary Transports,Transport, Mucociliary,Transports, Mucociliary
D003371 Cough A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs. Coughs
D003550 Cystic Fibrosis An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION. Mucoviscidosis,Cystic Fibrosis of Pancreas,Fibrocystic Disease of Pancreas,Pancreatic Cystic Fibrosis,Pulmonary Cystic Fibrosis,Cystic Fibrosis, Pancreatic,Cystic Fibrosis, Pulmonary,Fibrosis, Cystic,Pancreas Fibrocystic Disease,Pancreas Fibrocystic Diseases
D004338 Drug Combinations Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture. Drug Combination,Combination, Drug,Combinations, Drug
D005100 Expectorants Agents that increase mucous excretion. Mucolytic agents, that is drugs that liquefy mucous secretions, are also included here. Expectorant,Mucolytic,Mucolytic Agent,Mucolytic Agents,Mucolytics,Agent, Mucolytic,Agents, Mucolytic
D005260 Female Females
D005541 Forced Expiratory Volume Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity. Forced Vital Capacity, Timed,Timed Vital Capacity,Vital Capacity, Timed,FEVt,Capacities, Timed Vital,Capacity, Timed Vital,Expiratory Volume, Forced,Expiratory Volumes, Forced,Forced Expiratory Volumes,Timed Vital Capacities,Vital Capacities, Timed,Volume, Forced Expiratory,Volumes, Forced Expiratory

Related Publications

M Robinson, and J A Regnis, and D L Bailey, and M King, and G J Bautovich, and P T Bye
Hypertonic saline has a prolonged effect on mucociliary clearance in adults with cystic fibrosis.
September 2018, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society,
M Robinson, and J A Regnis, and D L Bailey, and M King, and G J Bautovich, and P T Bye
Effect of amiloride and saline on nasal mucociliary clearance and potential difference in cystic fibrosis and normal subjects.
August 1993, Thorax,
M Robinson, and J A Regnis, and D L Bailey, and M King, and G J Bautovich, and P T Bye
Inhalation of amiloride improves the mucociliary and the cough clearance in patients with cystic fibroses.
January 1986, European journal of respiratory diseases. Supplement,
M Robinson, and J A Regnis, and D L Bailey, and M King, and G J Bautovich, and P T Bye
Acute inhalation of hypertonic saline does not improve mucociliary clearance in all children with cystic fibrosis.
September 2011, BMC pulmonary medicine,
M Robinson, and J A Regnis, and D L Bailey, and M King, and G J Bautovich, and P T Bye
Effect of a short course of rhDNase on cough and mucociliary clearance in patients with cystic fibrosis.
July 2000, Pediatric pulmonology,
M Robinson, and J A Regnis, and D L Bailey, and M King, and G J Bautovich, and P T Bye
Effect of uridine 5'-triphosphate plus amiloride on mucociliary clearance in adult cystic fibrosis.
June 1996, American journal of respiratory and critical care medicine,
M Robinson, and J A Regnis, and D L Bailey, and M King, and G J Bautovich, and P T Bye
A four week trial of hypertonic saline in children with mild cystic fibrosis lung disease: Effect on mucociliary clearance and clinical outcomes.
November 2020, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society,
M Robinson, and J A Regnis, and D L Bailey, and M King, and G J Bautovich, and P T Bye
Mucociliary clearance and buffered hypertonic saline solution.
April 1997, The Laryngoscope,
M Robinson, and J A Regnis, and D L Bailey, and M King, and G J Bautovich, and P T Bye
Mucus clearance and lung function in cystic fibrosis with hypertonic saline.
January 2006, The New England journal of medicine,
M Robinson, and J A Regnis, and D L Bailey, and M King, and G J Bautovich, and P T Bye
A physiologically-motivated compartment-based model of the effect of inhaled hypertonic saline on mucociliary clearance and liquid transport in cystic fibrosis.
January 2014, PloS one,
Copied contents to your clipboard!