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The IE2 gene of human cytomegalovirus has been implicated in the development of coronary restenosis, and the gene product appears to inhibit p53-dependent transactivation. Here we describe an analysis of the IE2-p53 interaction. Repression of p53 function by IE2 requires two separable domains of IE2. The N terminus of IE2 interacts with p53. IE2 has little effect on the ability of p53 to bind specific DNA sequences. Reduction of the transactivation activity of p53 is caused by a transcriptional repression function contributed by the C-terminal domain of IE2. These findings suggest that IE2 may function as a transcriptional repressor, which is recruited to p53's target genes by interacting with p53.
H L Tsai, and
G H Kou, and
S C Chen, and
C W Wu, and
Y S Lin
January 1994,
Genes & development,
H L Tsai, and
G H Kou, and
S C Chen, and
C W Wu, and
Y S Lin
October 1997,
Journal of virology,
H L Tsai, and
G H Kou, and
S C Chen, and
C W Wu, and
Y S Lin
July 1998,
Journal of virology,
H L Tsai, and
G H Kou, and
S C Chen, and
C W Wu, and
Y S Lin
January 1993,
Proceedings of the National Academy of Sciences of the United States of America,
H L Tsai, and
G H Kou, and
S C Chen, and
C W Wu, and
Y S Lin
June 1996,
Journal of virology,
H L Tsai, and
G H Kou, and
S C Chen, and
C W Wu, and
Y S Lin
March 1997,
Biochemical and biophysical research communications,
H L Tsai, and
G H Kou, and
S C Chen, and
C W Wu, and
Y S Lin
April 2000,
The Journal of biological chemistry,
H L Tsai, and
G H Kou, and
S C Chen, and
C W Wu, and
Y S Lin
June 2000,
FEBS letters,
H L Tsai, and
G H Kou, and
S C Chen, and
C W Wu, and
Y S Lin
October 2000,
DNA and cell biology,
H L Tsai, and
G H Kou, and
S C Chen, and
C W Wu, and
Y S Lin
March 1998,
Cellular and molecular biology (Noisy-le-Grand, France),
