Biomaterial Database

High-performance liquid chromatographic determination of bisacodyl in pharmaceutical dosage forms marketed in Australia. 1995

K M Bradshaw, and J Burnett, and A S Sidhu

Pharmaceutical Chemistry Section, Therapeutic Goods Administration Laboratories, Woden, Australia.

HPLC methods have been developed for the assay of bisacodyl in various pharmaceutical forms. The extraction procedures are simple and the HPLC conditions separate bisacodyl from its degradation products. The chromatography was performed using a Merck LiChrospher RP-select B column, a mobile phase of 55% acetonitrile/45% 0.05 M KH2PO4 and detection by UV at 214 nm.

UI	MeSH Term	Description	Entries
D001726	Bisacodyl	A diphenylmethane stimulant laxative used for the treatment of CONSTIPATION and for bowel evacuation. (From Martindale, The Extra Pharmacopoeia, 30th ed, p871)	Agaroletten,Apo-Bisacodyl,Bekunis Bisacodyl,Bicol,Bisac-Evac,Bisacodyl Tannex,Bisacodyl Uniserts,Bisalax,Bisco-Lax,Bisco-Zitron,Dulco-Lax,Dulco-lax perles,Dulcolax,Durolax,Fleet Bisacodyl,Florisan N,Laxagetten,Laxanin,Laxans-ratiopharm,Laxbene,Laxysat Bürger,Lünolax,Rytmil,Ulcolax,ratio-Bisacodyl,Apo Bisacodyl,Bisac Evac,Bisacodyl, Bekunis,Bisacodyl, Fleet,Bisco Lax,Bisco Zitron,Dulco Lax,Dulco lax perles,Dulcolax perles,Laxans ratiopharm,Tannex, Bisacodyl,Uniserts, Bisacodyl,ratio Bisacodyl
D002400	Cathartics	Agents that are used to stimulate evacuation of the bowels.	Bowel Evacuant,Bowel Preparation Solution,Cathartic,Purgative,Purgatives,Bowel Evacuants,Bowel Preparation Solutions,Evacuant, Bowel,Evacuants, Bowel,Preparation Solution, Bowel,Preparation Solutions, Bowel,Solution, Bowel Preparation,Solutions, Bowel Preparation
D002851	Chromatography, High Pressure Liquid	Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.	Chromatography, High Performance Liquid,Chromatography, High Speed Liquid,Chromatography, Liquid, High Pressure,HPLC,High Performance Liquid Chromatography,High-Performance Liquid Chromatography,UPLC,Ultra Performance Liquid Chromatography,Chromatography, High-Performance Liquid,High-Performance Liquid Chromatographies,Liquid Chromatography, High-Performance
D004355	Drug Stability	The chemical and physical integrity of a pharmaceutical product.	Drug Shelf Life,Drugs Shelf Lives,Shelf Life, Drugs,Drug Stabilities,Drugs Shelf Life,Drugs Shelf Live,Life, Drugs Shelf,Shelf Life, Drug,Shelf Live, Drugs,Shelf Lives, Drugs
D012680	Sensitivity and Specificity	Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	Specificity,Sensitivity,Specificity and Sensitivity
D013488	Suppositories	Medicated dosage forms that are designed to be inserted into the rectal, vaginal, or urethral orifice of the body for absorption. Generally, the active ingredients are packaged in dosage forms containing fatty bases such as cocoa butter, hydrogenated oil, or glycerogelatin that are solid at room temperature but melt or dissolve at body temperature.	Rectal Suppositories,Vaginal Suppositories,Vaginal Suppository,Suppositories, Rectal,Suppositories, Vaginal,Suppository, Vaginal
D013607	Tablets	Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)	Tablet