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In humans, the relationship between advancing maternal age and the incidence of trisomy has been long established, but the possible effect of increasing age of the father remains controversial. Using a fluorescence in situ hybridization (FISH) approach to directly examine individual sperm for aneuploidy of the sex chromosomes and chromosome 18, we have analyzed approximately 400,000 sperm from 24 men aged 18-60 years. There was no obvious relationship between increasing age and disomy 18, but the incidence of XY,YY and XX disomy all were significantly elevated among older men. This suggests that older men, like older women, have an increased likelihood of producing aneuploid offspring by comparison with their younger counterparts.
D K Griffin, and
M A Abruzzo, and
E A Millie, and
L A Sheean, and
E Feingold, and
S L Sherman, and
T J Hassold
August 2002,
The Journal of urology,
D K Griffin, and
M A Abruzzo, and
E A Millie, and
L A Sheean, and
E Feingold, and
S L Sherman, and
T J Hassold
December 2001,
Fertility and sterility,
D K Griffin, and
M A Abruzzo, and
E A Millie, and
L A Sheean, and
E Feingold, and
S L Sherman, and
T J Hassold
November 2002,
Proceedings of the National Academy of Sciences of the United States of America,
D K Griffin, and
M A Abruzzo, and
E A Millie, and
L A Sheean, and
E Feingold, and
S L Sherman, and
T J Hassold
January 1997,
Cytogenetics and cell genetics,
D K Griffin, and
M A Abruzzo, and
E A Millie, and
L A Sheean, and
E Feingold, and
S L Sherman, and
T J Hassold
January 2016,
PloS one,
D K Griffin, and
M A Abruzzo, and
E A Millie, and
L A Sheean, and
E Feingold, and
S L Sherman, and
T J Hassold
October 2013,
Fertility and sterility,
D K Griffin, and
M A Abruzzo, and
E A Millie, and
L A Sheean, and
E Feingold, and
S L Sherman, and
T J Hassold
August 1998,
Human molecular genetics,
D K Griffin, and
M A Abruzzo, and
E A Millie, and
L A Sheean, and
E Feingold, and
S L Sherman, and
T J Hassold
June 2019,
Medicine,
D K Griffin, and
M A Abruzzo, and
E A Millie, and
L A Sheean, and
E Feingold, and
S L Sherman, and
T J Hassold
October 2018,
BMC genomics,
D K Griffin, and
M A Abruzzo, and
E A Millie, and
L A Sheean, and
E Feingold, and
S L Sherman, and
T J Hassold
January 2021,
Arab journal of urology,
