-transparent.png){kind=logo}
The purpose of this research is to study the relationship between chemical structure and inhibitory activity of some hydrazine-thiazole derivatives on rat liver mitochondria monoamine oxidase (MAO). Forty-five compounds belonging to three series of hydrazine-thiazole derivatives, with either alkylic or arylic substituents in the thiazole ring, were tested. The highest inhibitory activity was observed with piperonyl derivatives 25 and 40, which contain a 4-methyl group in the thiazole nucleus. The structure-activity relationship of MAO inhibitors was established in relation to hydrophobic, electronic and steric hindrance parameters. A mechanism of enzyme inhibition was proposed based on the calculation of HOMO energies.
G Raciti, and
P Mazzone, and
A Raudino, and
G Mazzone, and
A Cambria
September 1995,
Biochemical pharmacology,
G Raciti, and
P Mazzone, and
A Raudino, and
G Mazzone, and
A Cambria
May 1964,
Journal of medicinal chemistry,
G Raciti, and
P Mazzone, and
A Raudino, and
G Mazzone, and
A Cambria
February 1964,
Biochemical pharmacology,
G Raciti, and
P Mazzone, and
A Raudino, and
G Mazzone, and
A Cambria
January 1967,
Voprosy meditsinskoi khimii,
G Raciti, and
P Mazzone, and
A Raudino, and
G Mazzone, and
A Cambria
June 1994,
Biochemistry,
G Raciti, and
P Mazzone, and
A Raudino, and
G Mazzone, and
A Cambria
January 1966,
Federation proceedings. Translation supplement; selected translations from medical-related science,
G Raciti, and
P Mazzone, and
A Raudino, and
G Mazzone, and
A Cambria
December 1964,
Biulleten' eksperimental'noi biologii i meditsiny,
G Raciti, and
P Mazzone, and
A Raudino, and
G Mazzone, and
A Cambria
October 1978,
Archives of biochemistry and biophysics,
G Raciti, and
P Mazzone, and
A Raudino, and
G Mazzone, and
A Cambria
October 1969,
Biochemical pharmacology,
G Raciti, and
P Mazzone, and
A Raudino, and
G Mazzone, and
A Cambria
August 1973,
Journal of medicinal chemistry,
