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The lymphocyte response of dogs to mitogens was determined using separated lymphocyte and whole blood lymphocyte proliferation techniques. Reactivity to optimal doses of the following mitogens was demonstrated in decreasing order of intensity: phytohemagglutinin, Pokeweed mitogen, conconavalin A and sodium periodate. The canine cutaneous reactivity to these mitogens was also determined. Grossly, erythema and induration with all mitogens was maximal at 24 h. Microscopically, lesions using all mitogens consisted of edema, hyperemia and diffuse dermal infiltration with polymorphonuclear leukocytes and mononuclear cells. These mitogen-induced lesions may represent a specific lymphocyte-mediated inflammatory response, although a nonspecific reaction cannot be excluded.
M Schatz, and
R Patterson, and
H M Sommers, and
K E Harris
July 1995,
The Journal of investigative dermatology,
M Schatz, and
R Patterson, and
H M Sommers, and
K E Harris
January 1978,
Przeglad dermatologiczny,
M Schatz, and
R Patterson, and
H M Sommers, and
K E Harris
November 1982,
Immunology today,
M Schatz, and
R Patterson, and
H M Sommers, and
K E Harris
January 1979,
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association,
M Schatz, and
R Patterson, and
H M Sommers, and
K E Harris
January 1992,
Gynecologic and obstetric investigation,
M Schatz, and
R Patterson, and
H M Sommers, and
K E Harris
August 1976,
Journal of immunology (Baltimore, Md. : 1950),
M Schatz, and
R Patterson, and
H M Sommers, and
K E Harris
March 1967,
Journal of immunology (Baltimore, Md. : 1950),
M Schatz, and
R Patterson, and
H M Sommers, and
K E Harris
October 1994,
Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B,
M Schatz, and
R Patterson, and
H M Sommers, and
K E Harris
January 1987,
Revista latinoamericana de microbiologia,
M Schatz, and
R Patterson, and
H M Sommers, and
K E Harris
May 2001,
Fukuoka igaku zasshi = Hukuoka acta medica,
