Effect of SC-41930, a potent selective leukotriene B4 receptor antagonist, in the guinea pig model of middle ear inflammation. 1996

Y Sutbeyaz, and B Yakan, and H Ozdemir, and M Karasen, and F Doner, and I Kufrevioglu
Department of Otolaryngology, School of Medicine, Ataturk University, Erzurum, Turkey.

Arachidonic acid metabolites such as prostaglandins and leukotrienes have been shown to play an important role in the pathogenesis of otitis media (OM). Among these mediators, leukotriene B4 (LTB4) is one of the most potent inducers of inflammatory processes. SC-41930 has been shown to be a specific LTB4 receptor antagonist both in vitro and in vivo. In this study, anti-inflammatory effects of SC-41930 were investigated in a guinea pig model of OM induced by middle ear (ME) inoculation of killed Staphylococcus aureus. Outcome of treatment was determined by measurement of myeloperoxidase activity in the samples of ME mucosa, evaluation of temporal bone histopathology, and presence of ME fluids. Myeloperoxidase activity in the SC-41930-treated group was found to be significantly lower than that in the control group. Histopathology of temporal bones indicated decreased inflammation in the treated group as compared to the controls. In addition, ME fluids were absent in four out of six treated animals. These results demonstrate that SC-41930 can produce significant anti-inflammatory effects in this model of OM.

UI MeSH Term Description Entries
D010033 Otitis Media Inflammation of the MIDDLE EAR including the AUDITORY OSSICLES and the EUSTACHIAN TUBE. Middle Ear Inflammation,Inflammation, Middle Ear
D004432 Ear, Middle The space and structures directly internal to the TYMPANIC MEMBRANE and external to the inner ear (LABYRINTH). Its major components include the AUDITORY OSSICLES and the EUSTACHIAN TUBE that connects the cavity of middle ear (tympanic cavity) to the upper part of the throat. Tympanic Cavity,Tympanum,Middle Ear,Cavities, Tympanic,Cavity, Tympanic,Ears, Middle,Middle Ears,Tympanic Cavities,Tympanums
D006168 Guinea Pigs A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research. Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000894 Anti-Inflammatory Agents, Non-Steroidal Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. Analgesics, Anti-Inflammatory,Aspirin-Like Agent,Aspirin-Like Agents,NSAID,Non-Steroidal Anti-Inflammatory Agent,Non-Steroidal Anti-Inflammatory Agents,Nonsteroidal Anti-Inflammatory Agent,Anti Inflammatory Agents, Nonsteroidal,Antiinflammatory Agents, Non Steroidal,Antiinflammatory Agents, Nonsteroidal,NSAIDs,Nonsteroidal Anti-Inflammatory Agents,Agent, Aspirin-Like,Agent, Non-Steroidal Anti-Inflammatory,Agent, Nonsteroidal Anti-Inflammatory,Anti-Inflammatory Agent, Non-Steroidal,Anti-Inflammatory Agent, Nonsteroidal,Anti-Inflammatory Analgesics,Aspirin Like Agent,Aspirin Like Agents,Non Steroidal Anti Inflammatory Agent,Non Steroidal Anti Inflammatory Agents,Nonsteroidal Anti Inflammatory Agent,Nonsteroidal Anti Inflammatory Agents,Nonsteroidal Antiinflammatory Agents
D001578 Benzopyrans Compounds with a core of fused benzo-pyran rings. Benzopyran,Chromene,Chromenes
D013211 Staphylococcus aureus Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.
D018102 Receptors, Leukotriene B4 A class of cell surface leukotriene receptors with a preference for leukotriene B4. Leukotriene B4 receptor activation influences chemotaxis, chemokinesis, adherence, enzyme release, oxidative bursts, and degranulation in polymorphonuclear leukocytes. There are at least two subtypes of these receptors. Some actions are mediated through the inositol phosphate and diacylglycerol second messenger systems. LTB4 Receptors,Leukotriene B4 Receptors,LTB4 Receptor,Leukotriene B4 Receptor,Receptor, LTB4,Receptor, Leukotriene B4,Receptors, LTB4

Related Publications

Y Sutbeyaz, and B Yakan, and H Ozdemir, and M Karasen, and F Doner, and I Kufrevioglu
December 1990, Inflammation,
Y Sutbeyaz, and B Yakan, and H Ozdemir, and M Karasen, and F Doner, and I Kufrevioglu
November 1990, The Journal of pharmacology and experimental therapeutics,
Y Sutbeyaz, and B Yakan, and H Ozdemir, and M Karasen, and F Doner, and I Kufrevioglu
September 1991, Agents and actions,
Y Sutbeyaz, and B Yakan, and H Ozdemir, and M Karasen, and F Doner, and I Kufrevioglu
January 1992, The Journal of pharmacology and experimental therapeutics,
Y Sutbeyaz, and B Yakan, and H Ozdemir, and M Karasen, and F Doner, and I Kufrevioglu
June 1989, Agents and actions,
Y Sutbeyaz, and B Yakan, and H Ozdemir, and M Karasen, and F Doner, and I Kufrevioglu
June 1993, Inflammation,
Y Sutbeyaz, and B Yakan, and H Ozdemir, and M Karasen, and F Doner, and I Kufrevioglu
March 1991, Agents and actions,
Y Sutbeyaz, and B Yakan, and H Ozdemir, and M Karasen, and F Doner, and I Kufrevioglu
December 1989, Prostaglandins,
Y Sutbeyaz, and B Yakan, and H Ozdemir, and M Karasen, and F Doner, and I Kufrevioglu
June 1995, Inflammation,
Y Sutbeyaz, and B Yakan, and H Ozdemir, and M Karasen, and F Doner, and I Kufrevioglu
November 1995, American journal of respiratory and critical care medicine,
Copied contents to your clipboard!