BIOMAT Database Logo BIOMAT Database Logo

Circulating levels of immunoreactive parathyroid hormone-related protein and intact parathyroid hormone in human fetuses and newborns. 1996

N E Papantoniou, and P D Papapetrou, and A J Antsaklis, and P E Kontoleon, and S A Mesogitis, and D Aravantinos
First Department of Obstetrics and Gynecology, Alexandra State and University Maternity Hospital, Athens, Greece.

Undetectable or extremely low levels of circulating immunoreactive parathyroid hormone (PTH) have been reported in human newborns while PTH bioactivity was high. This prompted the hypothesis that the fetal calcemic hormone might be PTH-related protein. The purpose of this study was to measure circulating immunoreactive PTH-related protein in human fetuses and newborns in order to investigate this hypothesis. Parathyroid hormone-related protein (PTHrP(1-86) and intact PTH were measured using two-site immunoradiometric assays in plasma obtained by cordocentesis from 23 fetuses (19-33 weeks of gestation), from 17 newborns at term (38-41 weeks), from their mothers and from 22 normal women of reproductive age. Plasma PTHrP was detectable in all but one of the fetuses and newborns and in all the mothers and the controls. The mean level was similar among fetuses (19-33 weeks) (0.43 +/- 0.18 pmol/l), newborns (0.48 +/- 0.12), mothers (0.48 +/- 0.14) and normal controls (0.46 +/- 0.09). Plasma PTH was found to be significantly higher in fetuses at midgestation (1.0 +/- 0.99 pmol/l) than in the newborns (0.22 +/- 0.21) (p < 0.0025); maternal PTH was significantly higher compared to fetal level at mid-gestation (2.1 +/- 1.0, p < 0.01) as well as at term (2.69 +/- 1.40, p < 0.001). In the control women PTH was 3.07 +/- 1.25 pmol/l. These results showed that plasma amino-terminal PTHrP-(1-86) is detectable during the second half of human fetal life and its level remains unchanged during this period of time, in contrast to changing levels of fetal plasma PTH. The relatively low PTHrP-(1-86) level that we found in the newborns is not responsible for the high PTH-like bioactivity found by some investigators in cord blood at term.

UI MeSH Term Description Entries
D007231 Infant, Newborn An infant during the first 28 days after birth. Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D010281 Parathyroid Hormone A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates. Natpara,PTH (1-84),PTH(1-34),Parathormone,Parathyrin,Parathyroid Hormone (1-34),Parathyroid Hormone (1-84),Parathyroid Hormone Peptide (1-34),Hormone, Parathyroid
D010446 Peptide Fragments Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques. Peptide Fragment,Fragment, Peptide,Fragments, Peptide
D010455 Peptides Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are considered to be larger versions of peptides that can form into complex structures such as ENZYMES and RECEPTORS. Peptide,Polypeptide,Polypeptides
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D012016 Reference Values The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality. Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D002118 Calcium A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D005260 Female Females
D005312 Fetal Blood Blood of the fetus. Exchange of nutrients and waste between the fetal and maternal blood occurs via the PLACENTA. The cord blood is blood contained in the umbilical vessels (UMBILICAL CORD) at the time of delivery. Cord Blood,Umbilical Cord Blood,Blood, Cord,Blood, Fetal,Blood, Umbilical Cord,Bloods, Cord,Bloods, Fetal,Bloods, Umbilical Cord,Cord Blood, Umbilical,Cord Bloods,Cord Bloods, Umbilical,Fetal Bloods,Umbilical Cord Bloods
D005865 Gestational Age The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated from the onset of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization. It is also estimated to begin from fertilization, estrus, coitus, or artificial insemination. Embryologic Age,Fetal Maturity, Chronologic,Chronologic Fetal Maturity,Fetal Age,Maturity, Chronologic Fetal,Age, Embryologic,Age, Fetal,Age, Gestational,Ages, Embryologic,Ages, Fetal,Ages, Gestational,Embryologic Ages,Fetal Ages,Gestational Ages

Related Publications

N E Papantoniou, and P D Papapetrou, and A J Antsaklis, and P E Kontoleon, and S A Mesogitis, and D Aravantinos
Circulating levels of biologically active and immunoreactive intact parathyroid hormone in human newborns.
February 1991, Pediatric research,
N E Papantoniou, and P D Papapetrou, and A J Antsaklis, and P E Kontoleon, and S A Mesogitis, and D Aravantinos
Circulating intact parathyroid hormone levels in acute pancreatitis.
March 1994, The British journal of surgery,
N E Papantoniou, and P D Papapetrou, and A J Antsaklis, and P E Kontoleon, and S A Mesogitis, and D Aravantinos
Increased serum immunoreactive parathyroid hormone-related protein levels in chronic hypocalcemia.
March 1994, The Journal of clinical endocrinology and metabolism,
N E Papantoniou, and P D Papapetrou, and A J Antsaklis, and P E Kontoleon, and S A Mesogitis, and D Aravantinos
Circulating levels of immunoreactive parathyroid hormone in endemic genu valgum.
July 1976, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
N E Papantoniou, and P D Papapetrou, and A J Antsaklis, and P E Kontoleon, and S A Mesogitis, and D Aravantinos
Detection of immunoreactive parathyroid hormone-related protein in human cerebrospinal fluid.
January 1997, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association,
N E Papantoniou, and P D Papapetrou, and A J Antsaklis, and P E Kontoleon, and S A Mesogitis, and D Aravantinos
Circulating levels of midregional parathyroid hormone-related protein in hypercalcaemia of malignancy.
September 1992, Clinical endocrinology,
N E Papantoniou, and P D Papapetrou, and A J Antsaklis, and P E Kontoleon, and S A Mesogitis, and D Aravantinos
Effect of age on circulating immunoreactive and bioactive parathyroid hormone levels in women.
October 1987, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
N E Papantoniou, and P D Papapetrou, and A J Antsaklis, and P E Kontoleon, and S A Mesogitis, and D Aravantinos
The presence of immunoreactive parathyroid hormone-related protein in parathyroid adenoma cells.
January 1992, Acta pathologica japonica,
N E Papantoniou, and P D Papapetrou, and A J Antsaklis, and P E Kontoleon, and S A Mesogitis, and D Aravantinos
Circulating immunoreactive parathyroid hormone levels in premature infants and the response to calcium therapy.
September 1985, Acta paediatrica Scandinavica,
N E Papantoniou, and P D Papapetrou, and A J Antsaklis, and P E Kontoleon, and S A Mesogitis, and D Aravantinos
Immunoreactive parathyroid hormone-related protein: its association with preterm labor.
November 1995, European journal of obstetrics, gynecology, and reproductive biology,
Copied contents to your clipboard!