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Prophylatic treatment with a single dose of 1.0 or 2.0 mg/kg (body weight) of polyinosinic-polycytidylic acid stabilized with polylysine and carboxymethylcellulose (Poly ICLC), a potent interferon (IFN) inducer and immune enhancer, 18 h before intravenous inoculation of sporozoites (1.04 x 10(5)-0.70 x 10(6) sporozoites) of Plasmodium cynomolgi B in the rhesus monkey, completely abolished the infectivity of sporozoites. The inhibitory effect of Poly ICLC is dose dependent in monkeys infected with P. cynomolgi B sporozoites. Treatment with lower doses of Poly ICLC (0.5 mg/kg) provided significant protection, but the lowest dose of Poly ICLC used (0.1 mg/kg) failed to provide any protection. Prophylactic treatment with Poly ICLC, however, had no protective effect against trophozoite-induced infection.
S K Puri, and
G P Dutta, and
H B Levy, and
R K Maheshwari
January 1976,
The American journal of tropical medicine and hygiene,
S K Puri, and
G P Dutta, and
H B Levy, and
R K Maheshwari
April 1980,
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S K Puri, and
G P Dutta, and
H B Levy, and
R K Maheshwari
January 1947,
The Journal of infectious diseases,
S K Puri, and
G P Dutta, and
H B Levy, and
R K Maheshwari
November 2018,
Malaria journal,
S K Puri, and
G P Dutta, and
H B Levy, and
R K Maheshwari
February 1973,
Experimental parasitology,
S K Puri, and
G P Dutta, and
H B Levy, and
R K Maheshwari
March 1973,
The American journal of tropical medicine and hygiene,
S K Puri, and
G P Dutta, and
H B Levy, and
R K Maheshwari
June 1963,
JAMA,
S K Puri, and
G P Dutta, and
H B Levy, and
R K Maheshwari
June 1989,
Annals of tropical medicine and parasitology,
S K Puri, and
G P Dutta, and
H B Levy, and
R K Maheshwari
July 1969,
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S K Puri, and
G P Dutta, and
H B Levy, and
R K Maheshwari
January 1986,
Ji sheng chong xue yu ji sheng chong bing za zhi = Journal of parasitology & parasitic diseases,
