BIOMAT Database Logo BIOMAT Database Logo

Definition and refinement of a region of loss of heterozygosity at 11q23.3-q24.3 in epithelial ovarian cancer associated with poor prognosis. 1996

H Gabra, and J E Watson, and K J Taylor, and J Mackay, and R C Leonard, and C M Steel, and D J Porteous, and J F Smyth
Imperial Cancer Research Fund, Western General Hospital, Edinburgh, United Kingdom.

Previous cytogenetic and loss of heterozygosity (LOH) data suggest that disruption of chromosome 11q23-qter occurs frequently in epithelial ovarian cancer and is associated with an adverse clinicopathological phenotype. Ten polymorphic microsatellite repeat loci were analyzed by PCR from the 11q22-q25 region between D11S35 and D11S968 in 40 ovarian tumors (including 31 epithelial ovarian cancers). Two distinct regions of loss were detected, suggesting possible sites for genes involved in epithelial ovarian neoplasia: a large centromeric region between D11S35 and D11S933 (11q22-q23.3) and a telomeric 8.5-Mb region lying between D11S934 and D11S1320 (11q23.3-24.3) not previously defined. LOH of the latter region but not the former one was significantly associated with poor survival, despite all tumors in this study having LOH somewhere on chromosome 11. This analysis provides a starting point for positional cloning.

UI MeSH Term Description Entries
D010051 Ovarian Neoplasms Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. Cancer of Ovary,Ovarian Cancer,Cancer of the Ovary,Neoplasms, Ovarian,Ovary Cancer,Ovary Neoplasms,Cancer, Ovarian,Cancer, Ovary,Cancers, Ovarian,Cancers, Ovary,Neoplasm, Ovarian,Neoplasm, Ovary,Neoplasms, Ovary,Ovarian Cancers,Ovarian Neoplasm,Ovary Cancers,Ovary Neoplasm
D002277 Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for "cancer." Carcinoma, Anaplastic,Carcinoma, Spindle-Cell,Carcinoma, Undifferentiated,Carcinomatosis,Epithelial Neoplasms, Malignant,Epithelioma,Epithelial Tumors, Malignant,Malignant Epithelial Neoplasms,Neoplasms, Malignant Epithelial,Anaplastic Carcinoma,Anaplastic Carcinomas,Carcinoma, Spindle Cell,Carcinomas,Carcinomatoses,Epithelial Neoplasm, Malignant,Epithelial Tumor, Malignant,Epitheliomas,Malignant Epithelial Neoplasm,Malignant Epithelial Tumor,Malignant Epithelial Tumors,Neoplasm, Malignant Epithelial,Spindle-Cell Carcinoma,Spindle-Cell Carcinomas,Tumor, Malignant Epithelial,Undifferentiated Carcinoma,Undifferentiated Carcinomas
D002874 Chromosome Mapping Any method used for determining the location of and relative distances between genes on a chromosome. Gene Mapping,Linkage Mapping,Genome Mapping,Chromosome Mappings,Gene Mappings,Genome Mappings,Linkage Mappings,Mapping, Chromosome,Mapping, Gene,Mapping, Genome,Mapping, Linkage,Mappings, Chromosome,Mappings, Gene,Mappings, Genome,Mappings, Linkage
D002880 Chromosomes, Human, Pair 11 A specific pair of GROUP C CHROMOSOMES of the human chromosome classification. Chromosome 11
D005260 Female Females
D006579 Heterozygote An individual having different alleles at one or more loci regarding a specific character. Carriers, Genetic,Genetic Carriers,Carrier, Genetic,Genetic Carrier,Heterozygotes
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D016019 Survival Analysis A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function. Analysis, Survival,Analyses, Survival,Survival Analyses

Related Publications

H Gabra, and J E Watson, and K J Taylor, and J Mackay, and R C Leonard, and C M Steel, and D J Porteous, and J F Smyth
Definition and refinement of chromosome 11 regions of loss of heterozygosity in breast cancer: identification of a new region at 11q23.3.
July 1995, Cancer research,
H Gabra, and J E Watson, and K J Taylor, and J Mackay, and R C Leonard, and C M Steel, and D J Porteous, and J F Smyth
Loss of heterozygosity at BRCA1 locus is significantly associated with aggressiveness and poor prognosis in breast cancer.
May 2012, Annals of surgical oncology,
H Gabra, and J E Watson, and K J Taylor, and J Mackay, and R C Leonard, and C M Steel, and D J Porteous, and J F Smyth
CHD5 Downregulation Associated with Poor Prognosis in Epithelial Ovarian Cancer.
January 2011, Gynecologic and obstetric investigation,
H Gabra, and J E Watson, and K J Taylor, and J Mackay, and R C Leonard, and C M Steel, and D J Porteous, and J F Smyth
Definition of a region of loss of heterozygosity at chromosome 11q23.3-25 in head and neck squamous cell carcinoma using laser capture microdissection technique.
March 2004, Diagnostic molecular pathology : the American journal of surgical pathology, part B,
H Gabra, and J E Watson, and K J Taylor, and J Mackay, and R C Leonard, and C M Steel, and D J Porteous, and J F Smyth
M6P/IGF2R loss of heterozygosity in head and neck cancer associated with poor patient prognosis.
February 2003, BMC cancer,
H Gabra, and J E Watson, and K J Taylor, and J Mackay, and R C Leonard, and C M Steel, and D J Porteous, and J F Smyth
Loss of heterozygosity at chromosome 3p in epithelial ovarian cancer in China.
January 2002, International journal of gynecological cancer : official journal of the International Gynecological Cancer Society,
H Gabra, and J E Watson, and K J Taylor, and J Mackay, and R C Leonard, and C M Steel, and D J Porteous, and J F Smyth
Overexpression of HOXC8 is Associated With Poor Prognosis in Epithelial Ovarian Cancer.
July 2016, Reproductive sciences (Thousand Oaks, Calif.),
H Gabra, and J E Watson, and K J Taylor, and J Mackay, and R C Leonard, and C M Steel, and D J Porteous, and J F Smyth
Overexpression of ASAP1 is associated with poor prognosis in epithelial ovarian cancer.
January 2014, International journal of clinical and experimental pathology,
H Gabra, and J E Watson, and K J Taylor, and J Mackay, and R C Leonard, and C M Steel, and D J Porteous, and J F Smyth
Definition and refinement of chromosome 8p regions of loss of heterozygosity in gastric cancer.
April 2000, Clinical cancer research : an official journal of the American Association for Cancer Research,
H Gabra, and J E Watson, and K J Taylor, and J Mackay, and R C Leonard, and C M Steel, and D J Porteous, and J F Smyth
Mapping loss of heterozygosity at chromosome 13q: loss at 13q12-q13 is associated with breast tumour progression and poor prognosis.
December 1998, European journal of cancer (Oxford, England : 1990),
Copied contents to your clipboard!