-transparent.png){kind=logo}
We report the first series of studies comparing the anti-edematous effects of human corticotropin-releasing factor (hCRF) and dexamethasone in an experimental model of vasogenic peritumoral brain edema. Both hCRF and dexamethasone effectively decreased blood-brain barrier (BBB) permeability of intracerebral RG2 gliomas in rats as observed by contrast-enhanced T(1)-weighted magnetic resonance imaging. A decrease in the water content of tumor and peritumoral brain tissue was observed with proton-density magnetic resonance imaging and confirmed by direct wet/dry tissue measurements. The calculated ED(50) for hCRF was 59 micrograms/kg s.c. twice a day, and that for dexamethasone was 0.61 mg/kg i.m. twice a day; the hCRF:dexamethasone dose-potency ratio was 120:1 on a molar basis. The anti-edematous action of hCRF is not mediated by the release of adrenal corticosteroids. A direct action of hCRF on the tumor microvasculature results in restoration of BBB integrity and up-regulation of BBB-specific protein expression. The average survival time with chronic treatment was prolonged significantly in the hCRF-treated group (35 days) compared with the dexamethasone-treated group (28 days; P < 0.05) and the saline-treated control group (22 days; P < 0.0001). hCRF, as an alternative to corticosteroid therapy, may provide substantial benefits with respect to reducing the major side effects encountered with long-term, high-dose corticosteroid treatment.
J Tjuvajev, and
H Uehara, and
R Desai, and
B Beattie, and
C Matei, and
Y Zhou, and
M J Kreek, and
J Koutcher, and
R Blasberg
January 1990,
Journal of basic and clinical physiology and pharmacology,
J Tjuvajev, and
H Uehara, and
R Desai, and
B Beattie, and
C Matei, and
Y Zhou, and
M J Kreek, and
J Koutcher, and
R Blasberg
January 1980,
Advances in neurology,
J Tjuvajev, and
H Uehara, and
R Desai, and
B Beattie, and
C Matei, and
Y Zhou, and
M J Kreek, and
J Koutcher, and
R Blasberg
January 2000,
Zhonghua wai ke za zhi [Chinese journal of surgery],
J Tjuvajev, and
H Uehara, and
R Desai, and
B Beattie, and
C Matei, and
Y Zhou, and
M J Kreek, and
J Koutcher, and
R Blasberg
August 1983,
Science (New York, N.Y.),
J Tjuvajev, and
H Uehara, and
R Desai, and
B Beattie, and
C Matei, and
Y Zhou, and
M J Kreek, and
J Koutcher, and
R Blasberg
August 2022,
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP,
J Tjuvajev, and
H Uehara, and
R Desai, and
B Beattie, and
C Matei, and
Y Zhou, and
M J Kreek, and
J Koutcher, and
R Blasberg
December 2010,
Current opinion in molecular therapeutics,
J Tjuvajev, and
H Uehara, and
R Desai, and
B Beattie, and
C Matei, and
Y Zhou, and
M J Kreek, and
J Koutcher, and
R Blasberg
January 1990,
Annals of the New York Academy of Sciences,
J Tjuvajev, and
H Uehara, and
R Desai, and
B Beattie, and
C Matei, and
Y Zhou, and
M J Kreek, and
J Koutcher, and
R Blasberg
January 1982,
Endocrine reviews,
J Tjuvajev, and
H Uehara, and
R Desai, and
B Beattie, and
C Matei, and
Y Zhou, and
M J Kreek, and
J Koutcher, and
R Blasberg
May 1988,
Deutsche medizinische Wochenschrift (1946),
J Tjuvajev, and
H Uehara, and
R Desai, and
B Beattie, and
C Matei, and
Y Zhou, and
M J Kreek, and
J Koutcher, and
R Blasberg
March 1985,
Presse medicale (Paris, France : 1983),
