Absolute sterochemistry of the highly mutagenic 7,8-diol 9,10-epoxides derived from the potent carcinogen trans-7,8-dihydroxy-7,8-dihydrobenzol[a]pyrene.
1977
H Yagi, and
H Akagi, and
D R Thakker, and
H D Mah, and
M Koreeda, and
D M Jerina
UI
MeSH Term
Description
Entries
D009153
Mutagens
Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.
Clastogen,Clastogens,Genotoxin,Genotoxins,Mutagen
D002273
Carcinogens
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
Compounds of the general formula R-O-R arranged in a ring or crown formation.
Cyclic Ether,Cyclic Ethers,Ether, Cyclic
D001580
Benzopyrenes
A class of chemicals that contain an anthracene ring with a naphthalene ring attached to it.
Benzpyrene
D013237
Stereoisomerism
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)