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The cytotoxic effects of the following five hexane-related compounds were examined on Schwann cell DNA synthesis: 2,5-hexanedione (2,5-HD), 2-hexanol (2-OH), 2-hexanone (MnBK), 2,5-dimethylfuran (DF) and gamma-valerolactone (VL). Schwann cells were isolated from the sciatic nerves of neonatal Sprague-Dawley rats and cultured. [(3)H]-thymidine incorporation into Schwann cell nuclei was measured by scintillation spectrometry and autoradiography when hexane derivatives were added to the culture medium. All of the hexane-related compounds suppressed [(3)H]-thymidine incorporation in a concentration-dependent manner. DF was the most cytotoxic for the inhibition of Schwann cell DNA synthesis among the compounds. The finding suggests that DF-mediated cytotoxicity should be taken into account as a possible additional mechanism of hexane intoxication, especially in the impairment of mitotic cells.
M Kamijima, and
G Sobue, and
G Ichihara, and
E Shibata, and
Y Ono, and
H Kondo, and
M B Villanueva, and
T Itoh, and
T Mitsuma, and
Y Takeuchi
January 2000,
Journal of andrology,
M Kamijima, and
G Sobue, and
G Ichihara, and
E Shibata, and
Y Ono, and
H Kondo, and
M B Villanueva, and
T Itoh, and
T Mitsuma, and
Y Takeuchi
May 1996,
Glia,
M Kamijima, and
G Sobue, and
G Ichihara, and
E Shibata, and
Y Ono, and
H Kondo, and
M B Villanueva, and
T Itoh, and
T Mitsuma, and
Y Takeuchi
June 1999,
Toxicology and applied pharmacology,
M Kamijima, and
G Sobue, and
G Ichihara, and
E Shibata, and
Y Ono, and
H Kondo, and
M B Villanueva, and
T Itoh, and
T Mitsuma, and
Y Takeuchi
October 1979,
In vitro,
M Kamijima, and
G Sobue, and
G Ichihara, and
E Shibata, and
Y Ono, and
H Kondo, and
M B Villanueva, and
T Itoh, and
T Mitsuma, and
Y Takeuchi
January 1988,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
M Kamijima, and
G Sobue, and
G Ichihara, and
E Shibata, and
Y Ono, and
H Kondo, and
M B Villanueva, and
T Itoh, and
T Mitsuma, and
Y Takeuchi
August 1987,
The Journal of cell biology,
M Kamijima, and
G Sobue, and
G Ichihara, and
E Shibata, and
Y Ono, and
H Kondo, and
M B Villanueva, and
T Itoh, and
T Mitsuma, and
Y Takeuchi
January 1978,
Journal of neuropathology and experimental neurology,
M Kamijima, and
G Sobue, and
G Ichihara, and
E Shibata, and
Y Ono, and
H Kondo, and
M B Villanueva, and
T Itoh, and
T Mitsuma, and
Y Takeuchi
May 1978,
Experimental eye research,
M Kamijima, and
G Sobue, and
G Ichihara, and
E Shibata, and
Y Ono, and
H Kondo, and
M B Villanueva, and
T Itoh, and
T Mitsuma, and
Y Takeuchi
September 1984,
Developmental biology,
M Kamijima, and
G Sobue, and
G Ichihara, and
E Shibata, and
Y Ono, and
H Kondo, and
M B Villanueva, and
T Itoh, and
T Mitsuma, and
Y Takeuchi
December 1980,
Journal of neurochemistry,
