-transparent.png){kind=logo}
Binding of ribonucleoproteins to specific regions of mRNA can alter mRNA stability. This level of posttranscriptional regulation has been shown to play a major role in gene expression of eukaryotic cells. This process involves the binding of ribonucleoproteins to specific region(s) of unstable, rapidly degrading mRNAs such as those found in various cytokines, lymphokines, and oncogenes, thereby increasing the mRNA's stability. In many instances the instability of the mRNA has been mapped to an AU-rich motif in the 3' untranslated region. We transcribed RNA molecules containing four reiterations of an AUUUA motif, and demonstrated with RNA- band shift experiments that the AUUUA motif complexes with phosphorylated AUUUA-specific 43-47 kDa mRNA binding protein(s) found in the cytosol of both rat brain and cultured rat astrocytes.
D B Jacobs, and
A M Mandelin, and
T Giordano, and
I Xue, and
J S Malter, and
L D Singh, and
A K Snyder, and
S P Singh
November 1989,
Science (New York, N.Y.),
D B Jacobs, and
A M Mandelin, and
T Giordano, and
I Xue, and
J S Malter, and
L D Singh, and
A K Snyder, and
S P Singh
January 2000,
Biochemical and biophysical research communications,
D B Jacobs, and
A M Mandelin, and
T Giordano, and
I Xue, and
J S Malter, and
L D Singh, and
A K Snyder, and
S P Singh
August 1992,
Journal of molecular biology,
D B Jacobs, and
A M Mandelin, and
T Giordano, and
I Xue, and
J S Malter, and
L D Singh, and
A K Snyder, and
S P Singh
December 2010,
Biochemical Society transactions,
D B Jacobs, and
A M Mandelin, and
T Giordano, and
I Xue, and
J S Malter, and
L D Singh, and
A K Snyder, and
S P Singh
February 1999,
The Journal of biological chemistry,
D B Jacobs, and
A M Mandelin, and
T Giordano, and
I Xue, and
J S Malter, and
L D Singh, and
A K Snyder, and
S P Singh
August 1991,
Brain research. Molecular brain research,
D B Jacobs, and
A M Mandelin, and
T Giordano, and
I Xue, and
J S Malter, and
L D Singh, and
A K Snyder, and
S P Singh
August 2004,
Acta physiologica Scandinavica,
D B Jacobs, and
A M Mandelin, and
T Giordano, and
I Xue, and
J S Malter, and
L D Singh, and
A K Snyder, and
S P Singh
January 1979,
Methods in enzymology,
D B Jacobs, and
A M Mandelin, and
T Giordano, and
I Xue, and
J S Malter, and
L D Singh, and
A K Snyder, and
S P Singh
December 1991,
The EMBO journal,
D B Jacobs, and
A M Mandelin, and
T Giordano, and
I Xue, and
J S Malter, and
L D Singh, and
A K Snyder, and
S P Singh
April 1997,
The EMBO journal,
