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Twelve patients with either severe preeclampsia (9) or eclampsia (3) were treated with intravenous diazoxide, 300-mg bolus, for the reduction of diastolic blood pressure (less than or equal 110 torr) after the usual and customary measures had been initiated to include parenteral MgSO4 and diazepam. Diazoxide precipitously decreased both systolic and diastolic blood pressure proportionately (35-50%); the nadir was invariably reached in 5-15 minutes. Diastolic pressure never fell below 50 torr, and mean arterial pressure always exceeded 70 torr. Oliguria was not apparent. The vasodepressor response was fairly persistent for 4 hours in all but 3 patients; 2 of these received a second 300-mg dose. Significant changes in fetal heart activity (bradycardia, dysrhythmia) were observed in only 1 patient. Labor was immediately ablated in all patients, but could be restimulated with oxytocin. All pregnancies were terminated within 7 hours (mean, 3.7 hours), seven of them by cesarean section. Eleven newborns did well. We conclude that the immediate reduction in maternal arterial blood pressure is without apparent hazard to the mother as well as the fetus.
J A Morris, and
J J Arce, and
C J Hamilton, and
E C Davidson, and
J E Maidman, and
J H Clark, and
R S Bloom
October 1991,
Critical care clinics,
J A Morris, and
J J Arce, and
C J Hamilton, and
E C Davidson, and
J E Maidman, and
J H Clark, and
R S Bloom
January 1978,
Seminars in perinatology,
J A Morris, and
J J Arce, and
C J Hamilton, and
E C Davidson, and
J E Maidman, and
J H Clark, and
R S Bloom
August 1973,
The Australian & New Zealand journal of obstetrics & gynaecology,
J A Morris, and
J J Arce, and
C J Hamilton, and
E C Davidson, and
J E Maidman, and
J H Clark, and
R S Bloom
December 1969,
The American journal of cardiology,
J A Morris, and
J J Arce, and
C J Hamilton, and
E C Davidson, and
J E Maidman, and
J H Clark, and
R S Bloom
January 1980,
The Journal of the Association of Physicians of India,
J A Morris, and
J J Arce, and
C J Hamilton, and
E C Davidson, and
J E Maidman, and
J H Clark, and
R S Bloom
July 1974,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
J A Morris, and
J J Arce, and
C J Hamilton, and
E C Davidson, and
J E Maidman, and
J H Clark, and
R S Bloom
October 1976,
The Journal of the American Osteopathic Association,
J A Morris, and
J J Arce, and
C J Hamilton, and
E C Davidson, and
J E Maidman, and
J H Clark, and
R S Bloom
April 1983,
Ginecologia y obstetricia de Mexico,
J A Morris, and
J J Arce, and
C J Hamilton, and
E C Davidson, and
J E Maidman, and
J H Clark, and
R S Bloom
September 2019,
Global health, science and practice,
J A Morris, and
J J Arce, and
C J Hamilton, and
E C Davidson, and
J E Maidman, and
J H Clark, and
R S Bloom
October 2001,
Anesthesia and analgesia,
