Biomaterial Database

[Glutathione peroxidase and selenium-vitamin E deficiency in pigs (author's transl)]. 1977

P T Jensen

Glutathione peroxidase activity was measured, by the simple paper-fluorescent method of Board & Peter (1976), in blood samples from growing pigs(8 to 16 weeks old) originating from various production herds. The animals were divided in three different groups (Tables I and II): 1) Clinically normal animals from herds fed a selenium supplemented feed (about 0.1 ppm) (40 pigs, 5 herds). 2) Clinically normal animals from herds fed rations low in selenium feed (18 pigs, 3 herds). 3) Clinically normal pigs from litters fed rations with unknown selenium content and with at least one pig having died from Mulberry heart disease (MHD) or Hepatosis dietetica (HD) (Diagnosed at the State Veterinary Serum Laboratory) (40 pigs, 7 herds). The glutathione peroxidase activity was expressed as the reaction time (min.) corrected for haemoglobin concentration, as shown, in Fig. 1. and Equation A. The activity in whole blood was found significantly higher (P less than 0.001) in Group 1 than that in Group 2. The mean activity in Group 3 was significantly higher than in Group 2 (P less than 0.001) and significantly lower than in Group 1 (P less than 0.001). It is concluded that estimation of glutathione peroxidase activity may be useful in evaluating the "selenium status" in pigs.

UI	MeSH Term	Description	Entries
D010544	Peroxidases		Ovoperoxidase
D005979	Glutathione Peroxidase	An enzyme catalyzing the oxidation of 2 moles of GLUTATHIONE in the presence of HYDROGEN PEROXIDE to yield oxidized glutathione and water.	Cytosolic Glutathione Peroxidase,Glutathione Lipoperoxidase,Selenoglutathione Peroxidase,Glutathione Peroxidase, Cytosolic,Lipoperoxidase, Glutathione,Peroxidase, Glutathione,Peroxidase, Selenoglutathione
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012643	Selenium	An element with the atomic symbol Se, atomic number 34, and atomic weight 78.97. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE.	Selenium-80,Selenium 80
D013552	Swine	Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).	Phacochoerus,Pigs,Suidae,Warthogs,Wart Hogs,Hog, Wart,Hogs, Wart,Wart Hog
D013553	Swine Diseases	Diseases of domestic swine and of the wild boar of the genus Sus.	Disease, Swine,Diseases, Swine,Swine Disease
D014811	Vitamin E Deficiency	A nutritional condition produced by a deficiency of VITAMIN E in the diet, characterized by posterior column and spinocerebellar tract abnormalities, areflexia, ophthalmoplegia, and disturbances of gait, proprioception, and vibration. In premature infants vitamin E deficiency is associated with hemolytic anemia, thrombocytosis, edema, intraventricular hemorrhage, and increasing risk of retrolental fibroplasia and bronchopulmonary dysplasia. An apparent inborn error of vitamin E metabolism, named familial isolated vitamin E deficiency, has recently been identified. (Cecil Textbook of Medicine, 19th ed, p1181)	Deficiency, Vitamin E,Deficiencies, Vitamin E,Vitamin E Deficiencies