Biomaterial Database

Synthesis of some 3.4.5-trimethoxybenzyl derivatives of certain amino compounds likely to posses cns activity. 1977

A H Abo-Sier, and M M Badran, and M Khalifa

The condensation of 3.4.5-trimethoxybenzyl chloride with certain amines is described. Reacting the aralkyl chloride with 4-aminophenazone, 2-aminopyridine, piperidine, N-methylpiperazine, pyrrolidine and morpholine yielded the corresponding trimethoxybenzyl derivatives la--f. On the other hand, alpha-[3.4.5-trimethoxybenzamido]-glutarimide (2) was synthesized via the acylation of glutamic acid with trimethoxybenzoyl chloride, dehydration of the N-acyl derivative and finally imidation of the inner anhydride thus formed.

UI	MeSH Term	Description	Entries
D009025	Morpholines		Tetrahydro-1,4-Oxazines,Tetrahydro 1,4 Oxazines
D010879	Piperazines	Compounds that are derived from PIPERAZINE.
D010880	Piperidines	A family of hexahydropyridines.
D011759	Pyrrolidines	Compounds also known as tetrahydropyridines with general molecular formula (CH2)4NH.	Tetrahydropyridine,Tetrahydropyridines
D002490	Central Nervous System	The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges.	Cerebrospinal Axis,Axi, Cerebrospinal,Axis, Cerebrospinal,Central Nervous Systems,Cerebrospinal Axi,Nervous System, Central,Nervous Systems, Central,Systems, Central Nervous
D000632	Aminopyrine	A pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of AGRANULOCYTOSIS. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of CYTOCHROME P-450 metabolic activity in LIVER FUNCTION TESTS.	Amidophenazon,Aminophenazone,Dimethylaminophenazone,Dipyrine,Amidazophen,Amidophen,Amidopyrine,Aminofenazone,Dimethyl-N-aminoantipyrine,Dimethylaminoantipyrine,Eufibron,Dimethyl N aminoantipyrine
D000840	Anisoles	A group of compounds that are derivatives of methoxybenzene and contain the general formula R-C7H7O.	Methylphenyl Ethers,Ethers, Methylphenyl