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To determine whether changes in adrenergic nerve terminal activity may influence tissue metabolism of iodothyronines, sympathetic nervous function of the rat submaxillary salivary gland was altered, and effects on salivary gland triiodothyronine (T3) uptake and retention measured. Following unilateral superior cervical ganglionectomy, denervated salivary gland contained 24% less (p less than 0.02) radioimmunoassayable T3/mg and took up 20% less (p less than 0.001) intravenously administered 125I-T3/mg than the contralateral innervated gland. Effects were similar at 7, 14 and 56 days following ganglionectomy and could not be accounted for by post-denervation changes in the delivery of the isotope, in total salivary gland water, in vascular volume or in extracellular or intracellular fluid spaces. When reserpine was administered to unilaterally ganglionectomized animals, uptake of 125I-T3/mg in the innvervated gland was reduced by 10% (p less than 0.005), relative to the denervated gland. The results suggest that loss or diminution of peripheral adrenergic nerve terminal activity reduces tissue uptake and retention of T3.
M B Dratman, and
F L Crutchfield, and
J Axelrod, and
R D Utiger, and
E Marsh
January 1985,
Comparative biochemistry and physiology. A, Comparative physiology,
M B Dratman, and
F L Crutchfield, and
J Axelrod, and
R D Utiger, and
E Marsh
January 1951,
The New York state dental journal,
M B Dratman, and
F L Crutchfield, and
J Axelrod, and
R D Utiger, and
E Marsh
May 1981,
FEBS letters,
M B Dratman, and
F L Crutchfield, and
J Axelrod, and
R D Utiger, and
E Marsh
February 1984,
Journal of oral pathology,
M B Dratman, and
F L Crutchfield, and
J Axelrod, and
R D Utiger, and
E Marsh
January 1986,
Pflugers Archiv : European journal of physiology,
M B Dratman, and
F L Crutchfield, and
J Axelrod, and
R D Utiger, and
E Marsh
January 1978,
Bulletin de l'Academie polonaise des sciences. Serie des sciences biologiques,
M B Dratman, and
F L Crutchfield, and
J Axelrod, and
R D Utiger, and
E Marsh
January 1962,
Oral surgery, oral medicine, and oral pathology,
M B Dratman, and
F L Crutchfield, and
J Axelrod, and
R D Utiger, and
E Marsh
January 1987,
ORL; journal for oto-rhino-laryngology and its related specialties,
M B Dratman, and
F L Crutchfield, and
J Axelrod, and
R D Utiger, and
E Marsh
October 1966,
Ceskoslovenska stomatologie,
M B Dratman, and
F L Crutchfield, and
J Axelrod, and
R D Utiger, and
E Marsh
January 1996,
Anales otorrinolaringologicos ibero-americanos,
