Development of vaccines against falciparum malaria. 1996

S Ramalingam, and E Mathai
Christian Medical College, Vellore, Tamil Nadu, India.

Falciparum malaria is a leading cause of death in many countries. Drug resistance has emerged as a major cause for concern, increasing the pathogenic potential of the parasite. So far vaccines have been an elusive option. We discuss here some of the antigens and vaccines that show promise and on which studies are in progress.

UI MeSH Term Description Entries
D010963 Plasmodium falciparum A species of protozoa that is the causal agent of falciparum malaria (MALARIA, FALCIPARUM). It is most prevalent in the tropics and subtropics. Plasmodium falciparums,falciparums, Plasmodium
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000953 Antigens, Protozoan Any part or derivative of any protozoan that elicits immunity; malaria (Plasmodium) and trypanosome antigens are presently the most frequently encountered. Protozoan Antigens
D016778 Malaria, Falciparum Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations. Plasmodium falciparum Malaria,Malaria, Plasmodium falciparum
D017780 Malaria Vaccines Vaccines made from antigens arising from any of the four strains of Plasmodium which cause malaria in humans, or from P. berghei which causes malaria in rodents. Malaria Vaccine,Malarial Vaccine,Malarial Vaccines,Vaccine, Malaria,Vaccine, Malarial,Vaccines, Malaria,Vaccines, Malarial

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