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Colony-forming ability was employed in evaluating the susceptibility to in vitro gamma ionizing radiation in human diploid skin fibroblasts (HDF). Twelve pairs of HDF, each composed of fibroblasts from excised keloid lesion and local normal skin tissue as its control, were studied in patients with clinically persistent keloids. Parameters of radiosensitivity, both D0 and D10, and growth kinetics were examined. The radiosensitivity in three of the 12 keloids (25%) were demonstrated significantly increased than their counterpart controls, even though no difference in growth kinetics in between. Moreover, a broad range in the radiosensitivity of fibroblast cells was demonstrated and it is suggested that there is a great heterogeneity of cellular response to radiation in HDF.
S Ma, and
R H Fang, and
W P Chang
November 2003,
Toxicology,
S Ma, and
R H Fang, and
W P Chang
January 1984,
Science (New York, N.Y.),
S Ma, and
R H Fang, and
W P Chang
August 1974,
International journal of radiation biology and related studies in physics, chemistry, and medicine,
S Ma, and
R H Fang, and
W P Chang
January 1974,
Methods in enzymology,
S Ma, and
R H Fang, and
W P Chang
February 1995,
The Journal of investigative dermatology,
S Ma, and
R H Fang, and
W P Chang
December 1976,
Archivos de biologia y medicina experimentales,
S Ma, and
R H Fang, and
W P Chang
December 1988,
International journal of radiation biology,
S Ma, and
R H Fang, and
W P Chang
September 1982,
Mutation research,
S Ma, and
R H Fang, and
W P Chang
June 1976,
Experimental cell research,
S Ma, and
R H Fang, and
W P Chang
March 1979,
IEEE transactions on bio-medical engineering,
