-transparent.png){kind=logo}
Thirteen patients aged 24 to 65 with Cushing's disease have been treated by transphenoidal hypophysectomy. There was one incident of meningitis and one late death from myocarditis. No radiotherapy was given. In 12 patients pituitary histology showed Crooke's changes and an adenoma was present in seven. On review of the 12 survivors two to 11 years later, 11 are in complete remission. One patient still showed some clinical features of Cushing's syndrome but steroid levels were normal. In five of the seven premenopausal women normal menstruation has returned and pregnancy has occurred in three. In four patients replacement hormone therapy is no longer required and a further four take only partial treatment. We conclude that transphenoidal hypophysectomy is an effective treatment for Cushing's disease.
M H Carmalt, and
G A Dalton, and
R F Fletcher, and
W T Smith
August 1980,
Neurosurgery,
M H Carmalt, and
G A Dalton, and
R F Fletcher, and
W T Smith
April 1985,
Journal of the Royal Society of Medicine,
M H Carmalt, and
G A Dalton, and
R F Fletcher, and
W T Smith
January 1963,
Annales de radiologie,
M H Carmalt, and
G A Dalton, and
R F Fletcher, and
W T Smith
February 1971,
Otolaryngologic clinics of North America,
M H Carmalt, and
G A Dalton, and
R F Fletcher, and
W T Smith
April 1977,
Nursing mirror and midwives journal,
M H Carmalt, and
G A Dalton, and
R F Fletcher, and
W T Smith
June 1962,
The Journal of laryngology and otology,
M H Carmalt, and
G A Dalton, and
R F Fletcher, and
W T Smith
September 1964,
Journal of the Oto-laryngological Society of Australia,
M H Carmalt, and
G A Dalton, and
R F Fletcher, and
W T Smith
October 1965,
Nursing times,
M H Carmalt, and
G A Dalton, and
R F Fletcher, and
W T Smith
March 1968,
British journal of cancer,
M H Carmalt, and
G A Dalton, and
R F Fletcher, and
W T Smith
September 1981,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
