Biomaterial Database

Identification of drugs subtype-selective for alpha 2A-, alpha 2B-, and alpha 2C-adrenoceptors in the pig cerebellum and kidney cortex. 1995

A Wikberg-Matsson, and J E Wikberg, and S Uhlén

Department of Ophtalmology, Academic Hospital, Uppsala, Sweden.

The radioligands [3H]MK912 and [3H]RX821002 were used to label alpha2A-, alpha2B-, and alpha2C-adrenoceptors of the pig cerebellum and kidney cortex. By inclusion of the alpha2A-adrenoceptor-selective drug, BRL44408, and using a 'multi-curve' experimental design all the three porcine alpha2-adrenoceptor subtypes could be characterized pharmacologically. The data indicate that the pig alpha2-adrenoceptor subtypes are pharmacologically more related to human alpha2-adrenoceptor subtypes than to the rodent alpha2-adrenoceptors. We suggest a set of drugs that are useful for the delineation of the pig alpha2-adrenoceptor subtypes.

UI	MeSH Term	Description	Entries
D007093	Imidazoles	Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).
D007672	Kidney Cortex	The outer zone of the KIDNEY, beneath the capsule, consisting of KIDNEY GLOMERULUS; KIDNEY TUBULES, DISTAL; and KIDNEY TUBULES, PROXIMAL.	Cortex, Kidney
D011807	Quinolizines
D002531	Cerebellum	The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills.	Cerebella,Corpus Cerebelli,Parencephalon,Cerebellums,Parencephalons
D003984	Dibenzazepines	Compounds with two BENZENE rings fused to AZEPINES.
D004146	Dioxanes	Compounds that contain the structure 1,4-dioxane.
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001667	Binding, Competitive	The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.	Competitive Binding
D013552	Swine	Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).	Phacochoerus,Pigs,Suidae,Warthogs,Wart Hogs,Hog, Wart,Hogs, Wart,Wart Hog
D018341	Receptors, Adrenergic, alpha-2	A subclass of alpha-adrenergic receptors found on both presynaptic and postsynaptic membranes where they signal through Gi-Go G-PROTEINS. While postsynaptic alpha-2 receptors play a traditional role in mediating the effects of ADRENERGIC AGONISTS, the subset of alpha-2 receptors found on presynaptic membranes signal the feedback inhibition of NEUROTRANSMITTER release.	Adrenergic alpha-2 Receptors,Receptors, alpha-2 Adrenergic,alpha-2 Adrenergic Receptors,Adrenergic Receptor alpha(2C),Adrenergic Receptor alpha(2d),Adrenergic Receptor alpha-2C,Adrenergic Receptor alpha-2b,Adrenergic Receptor, alpha-2,Adrenergic alpha-2A Receptors,Adrenergic alpha-2B Receptors,Adrenergic alpha-2C Receptors,Adrenergic alpha-2D Receptors,Receptor, Adrenergic, alpha-2,Receptor, Adrenergic, alpha-2A,Receptor, Adrenergic, alpha-2B,Receptor, Adrenergic, alpha-2C,Receptor, Adrenergic, alpha-2D,Receptors, Adrenergic, alpha-2A,Receptors, Adrenergic, alpha-2B,Receptors, Adrenergic, alpha-2D,alpha 2 Adrenergic Receptors,alpha-2A Adrenergic Receptor,alpha-2B Adrenergic Receptor,alpha-2C Adrenergic Receptor,alpha-2D Adrenergic Receptor,Adrenergic Receptor alpha 2C,Adrenergic Receptor alpha 2b,Adrenergic Receptor, alpha 2,Adrenergic Receptor, alpha-2A,Adrenergic Receptor, alpha-2B,Adrenergic Receptor, alpha-2C,Adrenergic Receptor, alpha-2D,Adrenergic Receptors, alpha-2,Adrenergic alpha 2 Receptors,Adrenergic alpha 2A Receptors,Adrenergic alpha 2B Receptors,Adrenergic alpha 2C Receptors,Adrenergic alpha 2D Receptors,Receptor alpha-2C, Adrenergic,Receptor alpha-2b, Adrenergic,Receptor, alpha-2 Adrenergic,Receptor, alpha-2A Adrenergic,Receptor, alpha-2B Adrenergic,Receptor, alpha-2C Adrenergic,Receptor, alpha-2D Adrenergic,Receptors, Adrenergic alpha-2,Receptors, Adrenergic alpha-2A,Receptors, Adrenergic alpha-2B,Receptors, Adrenergic alpha-2C,Receptors, Adrenergic alpha-2D,Receptors, alpha 2 Adrenergic,alpha 2A Adrenergic Receptor,alpha 2B Adrenergic Receptor,alpha 2C Adrenergic Receptor,alpha 2D Adrenergic Receptor,alpha-2 Adrenergic Receptor,alpha-2 Receptors, Adrenergic,alpha-2A Receptors, Adrenergic,alpha-2B Receptors, Adrenergic,alpha-2C Receptors, Adrenergic,alpha-2C, Adrenergic Receptor,alpha-2D Receptors, Adrenergic,alpha-2b, Adrenergic Receptor