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Tertiary hyperparathyroidism after long-term phosphate supplementation in adult-onset hypophosphataemic osteomalacia. 1996
J Narváez, and
J Rodriguez-Moreno, and
C Moragues, and
E Campoy, and
T Clavaguera, and
D Roig-Escofet
Department of Rheumatology, Hospital Príncipes de España, Ciudad Sanitaria, Barcelona, Spain.
We report the development of tertiary hyperparathyrodism in a patient with a sporadic form of adult-onset hypophosphataemic osteomalacia who had been treated with vitamin D or calcitriol and large doses of phosphate. This observation suggests that even with concomitant vitamin D or calcitriol therapy, long-term oral phosphate supplementation may lead to the development of hypercalcaemic hyperparathyrodism. Caution is recommended when relatively large doses of phosphate are used to treat hypophosphataemic osteomalacia of diverse causes.
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