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Composition of sterols of the guinea pigs spinal cord unsaponifiables fraction was studied with experimental allergic encephalomyelitis (EAE). It is established that under conditions of EAE the cholesterol content is decreased by 48% as compared to normal. The amount of latosterol lowers as well and is 2.64 mg/g under normal conditions and 1.61 mg/g with EAE. A steroid compound which is more polar than cholesterol is found in the spinal cord. It is supposed to be cholesterol ether.
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