A modified technetium-99m isotope test to measure nasal mucociliary transport: comparison with the saccharine-dye test. 1995

K Ingels, and V Van Hoorn, and E Obrie, and K Osmanagaoglu
Department of Otorhinolaryngology, University Hospital Ghent, Belgium.

In this study two indirect mucociliary transport tests were compared. Nine subjects underwent duplicate saccharine-dye tests and duplicate modified technetium-99m (99mTc) tests, in which the radioactive 99mTc was nebulized in the nostril by means of a pump spray. The efficacy of mucociliary transport was deduced from the transport time of saccharine, dye and 99mTc. Transport rate also provided additional information in the 99mTc test. Transport rate correlated best in the repeated tests (r = 0.46), but was not significant (P = 0.21). Use of a pump spray for the 99mTc test instead of placement of a single droplet on the nasal mucosa makes the test easier to perform.

UI MeSH Term Description Entries
D007203 Indigo Carmine Indolesulfonic acid used as a dye in renal function testing for the detection of nitrates and chlorates, and in the testing of milk. Indigotindisulfonate Sodium,Soluble Indigo Blue,(delta-2,2'-biindole)-3,3'-dione,2-(1,3-Dihydro-3-oxo-5-sulpho-2H-indol-2-ylidene)-3- oxoindoline-5-sulphonic acid,D&C Blue NO. 6,FD&C Blue No. 2,Indigo,Indigo Blue,Indigo Disulfonate,Indigotin,Indigotindisulfonate,Indigotindisulfonic Acid,Carmine, Indigo,Indigo Blue, Soluble
D008297 Male Males
D009079 Mucociliary Clearance A non-specific host defense mechanism that removes MUCUS and other material from the LUNGS by ciliary and secretory activity of the tracheobronchial submucosal glands. It is measured in vivo as mucus transfer, ciliary beat frequency, and clearance of radioactive tracers. Mucociliary Transport,Clearance, Mucociliary,Clearances, Mucociliary,Mucociliary Clearances,Mucociliary Transports,Transport, Mucociliary,Transports, Mucociliary
D009297 Nasal Mucosa The mucous lining of the NASAL CAVITY, including lining of the nostril (vestibule) and the OLFACTORY MUCOSA. Nasal mucosa consists of ciliated cells, GOBLET CELLS, brush cells, small granule cells, basal cells (STEM CELLS) and glands containing both mucous and serous cells. Nasal Epithelium,Schneiderian Membrane,Epithelium, Nasal,Membrane, Schneiderian,Mucosa, Nasal
D009330 Nebulizers and Vaporizers Devices that cause a liquid or solid to be converted into an aerosol (spray) or a vapor. It is used in drug administration by inhalation, humidification of ambient air, and in certain analytical instruments. Atomizers,Inhalation Devices,Inhalators,Inhalers,Vaporizers,Nebulizers,Vaporizers and Nebulizers,Atomizer,Device, Inhalation,Devices, Inhalation,Inhalation Device,Inhalator,Inhaler,Nebulizer,Vaporizer
D010160 Palate, Soft A movable fold suspended from the posterior border of the hard palate. The uvula hangs from the middle of the lower border. Velum Palatinum,Soft Palate,Palates, Soft,Palatinum, Velum
D010614 Pharynx A funnel-shaped fibromuscular tube that conducts food to the ESOPHAGUS, and air to the LARYNX and LUNGS. It is located posterior to the NASAL CAVITY; ORAL CAVITY; and LARYNX, and extends from the SKULL BASE to the inferior border of the CRICOID CARTILAGE anteriorly and to the inferior border of the C6 vertebra posteriorly. It is divided into the NASOPHARYNX; OROPHARYNX; and HYPOPHARYNX (laryngopharynx). Throat,Pharynxs,Throats
D011877 Radionuclide Imaging The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph. Gamma Camera Imaging,Radioisotope Scanning,Scanning, Radioisotope,Scintigraphy,Scintiphotography,Imaging, Gamma Camera,Imaging, Radionuclide
D012044 Regression Analysis Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable. Regression Diagnostics,Statistical Regression,Analysis, Regression,Analyses, Regression,Diagnostics, Regression,Regression Analyses,Regression, Statistical,Regressions, Statistical,Statistical Regressions
D003679 Deglutition The act of taking solids and liquids into the GASTROINTESTINAL TRACT through the mouth and throat. Swallowing,Deglutitions,Swallowings

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