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A series of 13 oligodendrogliomas (WHO grade II) and 20 anaplastic oligodendrogliomas (WHO grade III) was studied for gene amplification and expression of the epidermal growth factor receptor gene (EGFR). EGFR gene amplification was found in only one case of anaplastic oligodendroglioma, which additionally showed a deletion/rearrangement at the 5' end of the gene. Northern blot analysis, however, revealed increases of EGFR mRNA expression relative to non-neoplastic control brain in 6 of 13 oligodendrogliomas and 10 of 18 anaplastic oligodendrogliomas. All cases with increased mRNA expression showed strong immunoreactivity for EGFR protein. Our findings thus indicate that increased expression of EGFR mRNA and protein is common in low-grade and high-grade oligodendroglial tumors and in the vast majority of cases is not caused by gene amplification.
J Reifenberger, and
G Reifenberger, and
K Ichimura, and
E E Schmidt, and
W Wechsler, and
V P Collins
August 2000,
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society,
J Reifenberger, and
G Reifenberger, and
K Ichimura, and
E E Schmidt, and
W Wechsler, and
V P Collins
January 1992,
In vivo (Athens, Greece),
J Reifenberger, and
G Reifenberger, and
K Ichimura, and
E E Schmidt, and
W Wechsler, and
V P Collins
January 2005,
In vivo (Athens, Greece),
J Reifenberger, and
G Reifenberger, and
K Ichimura, and
E E Schmidt, and
W Wechsler, and
V P Collins
October 2002,
Seminars in oncology,
J Reifenberger, and
G Reifenberger, and
K Ichimura, and
E E Schmidt, and
W Wechsler, and
V P Collins
January 1997,
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists,
J Reifenberger, and
G Reifenberger, and
K Ichimura, and
E E Schmidt, and
W Wechsler, and
V P Collins
April 2009,
Breast cancer research and treatment,
J Reifenberger, and
G Reifenberger, and
K Ichimura, and
E E Schmidt, and
W Wechsler, and
V P Collins
September 2001,
Clinical cancer research : an official journal of the American Association for Cancer Research,
J Reifenberger, and
G Reifenberger, and
K Ichimura, and
E E Schmidt, and
W Wechsler, and
V P Collins
November 2006,
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition,
J Reifenberger, and
G Reifenberger, and
K Ichimura, and
E E Schmidt, and
W Wechsler, and
V P Collins
January 2002,
The oncologist,
J Reifenberger, and
G Reifenberger, and
K Ichimura, and
E E Schmidt, and
W Wechsler, and
V P Collins
January 1992,
Journal of endocrinological investigation,
