[Eosinophilic reactions in patients with bronchial asthma and possibilities of their neutralization during health resort treatment]. 1995

L M Okopnaia, and V N Zorin, and Kaladzhiia Vassim, and I M Padalka, and T M Glazatova

Patients with the eosinophilic variant of bronchial asthma were found to be characterized by a high level of fibrinolytic activity in bronchial secretion and a low level of IgA in it, as was detected in the course of health resort treatment. The said changes were as a rule not corrected by routine spa therapy. Addition of sodium hydrocarbonate and heparin aerosols to the therapeutic complex was conducive to neutralization of cationic proteins and of the major eosinophilic protein in the bronchial lumen. These measures led to normalization of IgA level in the sputum and to reduction of the fibrinolytic activity of the sputum.

UI MeSH Term Description Entries
D007070 Immunoglobulin A Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions. IgA,IgA Antibody,IgA1,IgA2,Antibody, IgA
D004804 Eosinophils Granular leukocytes with a nucleus that usually has two lobes connected by a slender thread of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin. Eosinophil
D005342 Fibrinolysis The natural enzymatic dissolution of FIBRIN. Fibrinolyses
D006294 Health Resorts Destinations frequented as vacation or recreational retreats, equipped with specialized amenities, treatments and facilities, for the promotion of general well-being and health. Health Resort,Resort, Health,Resorts, Health
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001249 Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL). Asthma, Bronchial,Bronchial Asthma,Asthmas
D013183 Sputum Material coughed up from the lungs and expectorated via the mouth. It contains MUCUS, cellular debris, and microorganisms. It may also contain blood or pus. Sputum, Induced,Induced Sputum,Induced Sputums,Sputums,Sputums, Induced

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